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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study planned
Justification for type of information:
TESTING PROPOSAL
- The test item caused certain toxicity on Daphnia Magna and Green algae. The 48-h LC50 on Daphnia Magna was determined to be 32 mg/l and the 72h EC50 on Green algae was found to be 7.9 mg/l. Therefore, it is suggested to conduct a long-term toxicity study on the same species over 21 days.

NON-CONFIDENTIAL NAME OF SUBSTANCE:
- The substance to be registered is a dianhydride and unstable in water. Therefore, the hydrolysis product needs to be tested; the name of the substance on which testing is proposed to be carried out: Pyromellitic acid (Benzene-1,2,4,5-tetracarboxylic acid / 89-05-4 / 201-879-5

CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies: acute toxicity on aquatic invertebrates (EC50: 32 mg/L), acute toxicity on fish (LC50: > 100 mg/l) and algal growth inhibition test (EC50: 7.9 mg/l)
- Available non-GLP studies: none
- (Q)SAR: none
- In vitro methods: none
- Weight of evidence: none
- Grouping and read-across: hydrolysis product PMA needs to be tested, as substance to be registered in unstable in water
- Substance-tailored exposure driven testing [if applicable]: not applicable

Qualifier:
according to
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Deviations:
no

Description of key information

The test item caused certain toxicity on Daphnia Magna and Green algae. The 48-h LC50 on Daphnia Magna was determined to be 32 mg/l and the 72h EC50 on Green algae was found to be 7.9 mg/l. Therefore, it is suggested to conduct a long-term toxicity study on the same species over 21 days. The substance to be registered is a dianhydride and unstable in water. Therefore, the hydrolysis product needs to be tested; the name of the substance on which testing is proposed to be carried out: Pyromellitic acid (Benzene-1,2,4,5-tetracarboxylic acid / CAS-no. 89-05-4 / EC-no. 201-879-5).

Key value for chemical safety assessment

Additional information