Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Hydrolysis as a function of pH at 25degrees C. Federal Register Vol. 50, No. 188 (1985) Rules and Regulations p 39252
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyridine-2-thiol 1-oxide, sodium salt
EC Number:
223-296-5
EC Name:
Pyridine-2-thiol 1-oxide, sodium salt
Cas Number:
3811-73-2
Molecular formula:
C5H5NOS.Na
IUPAC Name:
sodium (1-oxo-1lambda5-pyridin-2-yl)sulfanide
Details on test material:
- Analytical purity: 40%
- Lot/batch No.: 64/95

Study design

Analytical monitoring:
yes
Details on sampling:
- Sampling intervals: 0, 7, 14, 21, 28 days
Buffers:
pH3 buffer: 500ml 0.1M KH-phthalate + 222ml 0.1M HCl adjusted to 1L with deionised water
pH7 buffer: 500ml 0.1M KH2-phosphate + 290ml 0.1M NaOH adjusted to 1L with deionised water
pH11 buffer: 500ml 0.05M Na-bicarbonate + 226ml 0.1M NaOH adjusted to 1L with deionised water
Duration of test
Duration:
28 d
Initial conc. measured:
140 mg/L
Number of replicates:
3 per pH

Results and discussion

Transformation products:
no
Total recovery of test substance (in %)open allclose all
% Recovery:
86
pH:
3
Temp.:
25 °C
Duration:
7 d
% Recovery:
86
pH:
3
Temp.:
25 °C
Duration:
14 d
% Recovery:
100
pH:
3
Temp.:
25 °C
Duration:
21 d
% Recovery:
93
pH:
3
Temp.:
25 °C
Duration:
28 d
% Recovery:
100
pH:
7
Temp.:
25 °C
Duration:
7 d
% Recovery:
95
pH:
7
Temp.:
25 °C
Duration:
14 d
% Recovery:
100
pH:
7
Temp.:
25 °C
Duration:
21 d
% Recovery:
100
pH:
7
Temp.:
25 °C
Duration:
28 d
% Recovery:
112
pH:
11
Temp.:
25 °C
Duration:
7 d
% Recovery:
91
pH:
11
Temp.:
25 °C
Duration:
14 d
Dissipation DT50 of parent compound
pH:
3
Temp.:
25 °C
DT50:
> 1 yr
Details on results:
Hydrolysis rate constant (Kh) is zero for each of the pHs

Any other information on results incl. tables

 

pH

 

Sampling times (days)

Percent prepared concentration

7

14

21

28

 

 

 

 

3

86

86

100

93

 

 

 

 

7

100

95

100

100

 

 

 

 

11

112

91

98

100

 

 

 

 

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
No DT50 for hydrolysis could be determined after 28 days in pH 3, 7, and 11 buffer. The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under Regulation EC 1907/2006.