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Short-term toxicity to fish

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Description of key information

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.007 mg/L

Additional information

See Tables 6.1.1.1, 6.1.1.2, 6.1.1.3, and 6.1.1.4 for summaries on the acute toxicity to fish of sodium pyrithione and its metabolites.

The acute studies on fish indicate that NaPT is toxic to fish. The LC50values range from 0.0066 to 1.3 mg NaPT/L with Onchorynchus mykiss (rainbow trout) being the most sensitive species. The NOEC for this study was 0.0026 mg NaPT/L.

Further, acute toxicity studies in fish for the major metabolites indicate that the most toxic substance is Pyrithione disulphide with a NOEC of 0.011 mg/L, to the freshwater species Pimephales promelas (Fathead Minnow), but that this is many times less toxic than the parent compound Sodium Pyrithione. However, Pyrithione disulphide is very short lived in the environment (photolytic half-life is 2.5 minutes) and the most relevant degradant of NaPT is Pyridine sulphonic acid (PSA). The NOEC for PSA is 46.9 mg/L for the rainbow trout.

Table 6.1.1.1:    Acute toxicity of NaPT to fish

Guideline /
Test method

Species

End-point /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

design

duration

NOEC

LC50

LC100

 

US EPA-540/9-85-006

Freshwater

Rainbow trout

 

Oncorhyncus mykiss

 

Mortality

Flow-through

96 hours

1.000

1.300

>1.300

 

6.1.1.001

ESPTF 7041-101

Croudace et al (1996)

U.S. EPA-FIFRA, Guideline 72-1

(comparableto OECD 203)

Freshwater

Rainbow trout

 

Oncorhyncus mykiss

 

Mortality

Flow-through

96 hours

0.0026

0.0066

0.011

 

Key Study

 

6.1.1.002

ESPTF 7041-102

O’Boyle et al (1988)

U.S. EPA-FIFRA, Guideline 72-1

(comparableto OECD 203)

Bluegill sunfish

(Lepomis Machrochirus).

 

Mortality

Flow-through

96 hours

0.88

9.6

n.a.

 

6.1.1.003

ESPTF 7041-103

Ewell et al (1987)

 

Table 6.1.1.2:    Acute toxicity of Pyridine-N-oxide-2-sulfonic acid to fish

Guideline /
Test method

Species

End-point /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

design

duration

NOEC

LC50

LC100

 

US EPA-

72-1

Freshwater

Fathead Minnow

 

Pimephales promelas

 

Mortality

 

Flow-through

96 hours

48.7

58.8

 

Key study

6.1.1.009

EZPTF 7041-117

Ward TJ, Kowalski PL, Boeri RL (1994)

US EPA-

72-1

Freshwater

Rainbow trout

 

Oncorhyncus mykiss

 

Mortality

 

Flow-through

96 hours

73.6

92.3

 

 

6.1.1.005

EZPTF 7041-111

Ward TJ, Kowalski PL, Boeri RL (1994)

US EPA-

72-3 (b)

Marine

Sheepshead Minnow

 

Cyprinodon variegatus

Mortality

 

Flow-through

96 hours

137

>137

6.1.1.007

EZPTF 7041-114

Boeri RL, Kowalski PL, Ward TJ (1994)

 

Table 6.1.1.3:    Acute toxicity of Pyridine sulphonic acid to fish

Guideline /
Test method

Species

End-point /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

design

duration

NOEC

LC50

LC100

 

US EPA-

72-1

Freshwater

Fathead Minnow

 

Pimephales promelas

 

Mortality

 

Flow-through

96 hours

55.2

68.5

6.1.1.010

EZPTF 7041-118

Boeri RL, Kowalski PL, Ward TJ (1994)

US EPA-

72-1

Freshwater

Rainbow trout

 

Oncorhyncus mykiss

 

Mortality

 

Flow-through

96 hours

46.9

57.1

 

 

6.1.1.006

EZPTF 7041-112

Ward TJ, Kowalski PL, Boeri RL (1993)

US EPA-

72-3 (b)

Marine

Sheepshead Minnow

 

Cyprinodon variegatus

Mortality

 

Flow-through

96 hours

127

>127

6.1.1.008

EZPTF 7041-115

Boeri RL, Kowalski PL, Ward TJ (1994)

 

Table 6.1.1.4:    Acute toxicity of 2,2’-(pyridyl-N-oxide) disulphide to fish

Guideline /
Test method

Species

End-point /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

design

duration

NOEC

LC50

LC100

 

US EPA-

72-1

Freshwater

Fathead Minnow

 

Pimephales promelas

 

Mortality

 

Flow-through

96 hours

0.011

0.030

6.1.1.004

EZPTF 7041-116

Ward TJ, Magazu JP, Boeri RL (1995)

US EPA-

72-1

Freshwater

Rainbow trout

 

Oncorhyncus mykiss

 

Mortality

 

Flow-through

96 hours

0.018

0.054

6.1.1.011

EZPTF 7041-110

Ward TJ, Magazu JP, Boeri RL (1995)

US EPA-

72-3 (b)

Marine

Sheepshead Minnow

 

Cyprinodon variegatus

Mortality

 

Flow-through

96 hours

<0.52

1.1

6.1.1.012

EZPTF 7041-113

Ward TJ, Magazu JP, Boeri RL (1995)

  The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.