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Short-term toxicity to aquatic invertebrates

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Description of key information

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.022 mg/L

Additional information

See Tables 6.1.3.1, 6.1.3.2, 6.1.3.3, and 6.1.3.4 for summaries on the acute toxicity to invertebrates of sodium pyrithione and its metabolites.

Acute studies on invertebrates indicate that NaPT is toxic. The LC50values range from 0.022 to 0.15 mg NaPT/L.The lowest NOEC for these studies was 0.011 mg NaPT/L.

 

Further, acute toxicity studies in fish for the major metabolites indicate that the most toxic substance is Pyrithione disulphide with a NOEC of 0.006 mg/L, to daphnia magna. Pyrithione disulphide is very short lived in the environment and the most relevant degradant of NaPT is Pyridine sulphonic acid (PSA). The NOEC for PSA is 51.1 for the eastern oyster.

Table 6.1.3.1:           Acute toxicity of NaPT to invertebrates

Guideline /
Test method

Species

Endpoint /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

 

design

duration

NOEC

LC50

LC100

 

OECD 202.
92/69/EEC, C.2.

Daphnia magna

Immobilis-ation

Static

48 hours

0.02

0.15

1.3

 

6.1.3.001

ESPTF 7041-201

Smith et al (1994)

 

U.S. EPA-FIFRA, Guideline 72-2

 

Daphnia magna

Immobilis-ation

Flow through

48 hours

0.011

0.022

>0.037

6.1.3.002

ESPTF 7041-202

Smith et al (1994)


Table 6.1.3.2:    Acute toxicity of Pyridine-N-oxide-2-sulfonic acid to invertebrates

Guideline /
Test method

Species

Endpoint /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

 

design

duration

NOEC

LC50

EC50

 

US EPA-

 72-2

 

Daphnia magna

Immobility and mortality

 

Flow-through

48 hours

127

 

>127

 

6.1.3.005

EZPTF 7041-211

Ward TJ, Kowalski PL, Boeri RL (1994)

US EPA – 72-3(b)

Mysid

 

Mysidopsis bahia

 

Mortality

Static

96 hours

32.2

71.3

 

 

6.1.3.007

EZPTF 7041-214

Ward TJ, Kowalski PL, Boeri RL (1994

US EPA

eastern oysterCrassostrea virginica

Shell growth

Flow-through

96 hours

35.6

 

99.2

6.1.3.014

EZPTF 7041-217

Boeri RL, Kowalski PL, Ward TJ (1994)

 

 

Table 6.1.3.3:    Acute toxicity of Pyridine Sulphonic acid to invertebrates

Guideline /
Test method

Species

Endpoint /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

 

design

duration

NOEC

LC50

EC50

 

US EPA-

 72-2

 

Daphnia magna

Immobility and mortality

 

Flow-through

48 hours

122

 

>122

 

6.1.3.006

EZPTF 7041-212

Ward TJ, Kowalski PL, Boeri RL (1994)

US EPA – 72-3(b)

Mysid –

 

Mysidopsis bahia

Mortality

Flow-through

96 hours

51.9

71.6

 

6.1.3.008

EZPTF 7041-215

Ward TJ, Kowalski PL, Boeri RL (1994)

 

US EPA

eastern oysterCrassostrea virginica

Shell growth

Flow-through

96 hours

51.1

85.6

 

Key study

 

6.1.3.009

EZPTF 7041-218

Boeri RL, Kowalski PL, Ward TJ (1994)

 

 

Table 6.1.3.4:    Acute toxicity of 2,2’-(pyridyl-N-oxide) disulphide to invertebrates

Guideline /
Test method

Species

Endpoint /
Type of test

Exposure

Results

[mg/L]

Remarks

Reference

 

design

duration

NOEC

LC50

EC50

 

US EPA-

 72-2

 

Daphnia magna

Immobility and mortality

 

Flow-through

48 hours

0.006

 

0.013

6.1.3.011

EZPTF 7041-210

Ward TJ, Magazu JP, Boeri RL (1995)

US EPA- 72-3(b)

Mysidopsis bahia

Mortality

static

96 hours

0.004

0.0064

 

6.1.3.012

EZPTF 7041-213

Ward TJ, Magazu JP, Boeri RL (1995)

US EPA – 72-3(c)

eastern oysterCrassostrea virginica

Shell growth

Flow-through

96 hours

0.110

 

0.16

6.1.3.013

EZPTF 7041-216

Ward TJ, Magazu JP, Boeri RL (1995)

 

  The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.