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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

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Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Particle size distribution , fibre length and diameter distribution.
Version / remarks:
June 1996 European Commission technical guidance document
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
cascade impaction
Type of particle tested:
primary particle
Type of distribution:
mass based distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyridine-2-thiol 1-oxide, sodium salt
EC Number:
223-296-5
EC Name:
Pyridine-2-thiol 1-oxide, sodium salt
Cas Number:
3811-73-2
Molecular formula:
C5H5NOS.Na
IUPAC Name:
sodium (1-oxo-1λ⁵-pyridin-2-yl)sulfanide
Test material form:
solid

Results and discussion

Remarks on result:
not determinable
Remarks:
Too few particles were of a size less than 10 µm to allow accurate assessment of MMAD and GSD.
Particle size distribution at different passagesopen allclose all
No.:
#1
Size:
10 µm
Distribution:
3.24 %
No.:
#2
Size:
10 µm
Distribution:
2.91 %
No.:
#3
Size:
10 µm
Distribution:
1.72 %

Any other information on results incl. tables

The results of the preliminary sieving test provided a % mass of test material less than the sieve aperature size (100 µm) of 61.7%.

Applicant's summary and conclusion

Conclusions:
The results of the present study indicate that the proportion of mass by particles which, if inhaled, can be expected to achieve alveolar deposition in man is 2.62%.