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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1977

Materials and methods

Principles of method if other than guideline:
BASF-Test, see details in remarks on matrial and methods.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Phthalid

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.9 - 3.2 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
water
Controls:
other: untreated skin of the same animal served as control
Amount / concentration applied:
80 % in water
Duration of treatment / exposure:
1, 5, 15 min, 20 h
Observation period:
8 days
Number of animals:
2
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol concentrated and Lutrol diluted to 50 % with warm water
- Time after start of exposure: 1, 5, 15 min and 20 h, respectively


SCORING SYSTEM:
The original scoring system was converted into Draize scores.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h - 48 h - 72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h - 48 h - 72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects

Any other information on results incl. tables

Readings

Animal

 Exposure period: 20 h

Erythema

Edema

Additional findings

1 h

1

0

0

2

0

0

24 h

1

0

0

2

0

0

48 h

1

0

0

2

0

0

72 h

1

0

0

2

0

0

Mean

24, 48, 72 h

1

0

0

2

0

0

Mean 24, 48, 72 h

1-2

0

0

No erythema and no edema were observed (score 0 according to the OECD/Draize scheme).

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information