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Description of key information

Short description of key information on bioaccumulation potential result: 
One reliable result regarding the analogue of the substance is available. Excretion as indicator of exposure to phthalic anhydride was measured in humans inhaling 0.03-10.5 mg/m3 (Pfaeffli P., 1986). Low exposition (0.15 mg/m3): no phthalic acid excreted; middle exposition (1.63 mg/m3): 1.02 ┬Ámol phthalic acid/mmol creatinine. High exposition (10.5 mg/m3): 4.8 ┬Ámol phthalic acid/mmol creatinine.

Key value for chemical safety assessment

Additional information

At low atmospheric phthalic anhydride concentrations the excretion of phthalic acid increased from the pre-shift concentration to the post-shift concentration and decreased then until the pre-shift concentration was again reached. The pre-shift phthalic acid concentration in the urine was not significantly different from those of occupationally unexposed people. Exposure to higher concentrations of phthalic anhydride in air resulted in a body load of phthalic acid which was not totally cleared overnight, and with pre-shift phthalic acid concentrations in the urine with a mean value three times the mean control value. Workers occupationally exposed to atmospheric phthalic anhydride absorbed the substance with some being excreted in the urine as unconjugated phthalic acid.