Registration Dossier

Administrative data

Description of key information

One reliable study (BASF XXVI/48, 1976) covering oral, inhalative and other routes acute toxicity is available. The resulting LD50 in rats is about 5600 mg/kg bw, no mortalities were found in an inhalation risk test in rats within 8h and intraperitoneal injection gave an LD50 between 1000 and 1470 mg/kg bw in mice. Regarding dermal acute toxicity there is only secondary literature for phthalic anhydride available (Biofax 13-4/1970) stating an LD 50 of 10000 mg/kg bw. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
5 600 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
10 000 mg/kg bw

Additional information

The substance was tested for acute toxicity orally, inhalative and intraperitoneally - the dermal LD50 was investigated by phthalic anhydride. No mortality or other symptoms were found after an 8 h exposure in an inhalation risk test. Symptoms and a bad general condition were found after oral, dermal or intraperitoneal exposure but only at doses above the classification threshold.

Justification for classification or non-classification