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Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report Date:
1996

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Test material form:
solid
Details on test material:
- State of aggregation: white, homogeneous melt
- Chemical name: Phthalid, 1 ( 3 H)-Isobenzofuranon

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
1.32
Temp.:
25 °C
pH:
7.5

Any other information on results incl. tables

Results

Compound

tr[min]

(mean value out of thre determinations)

log ks

log Pow

Formamide t0

2.71

-

-

Acetanilide

4.02

-0.31

1.0

Benzyl alkocol

4.06

-0.30

1.1

p-Methoxyphenol

4.07

-0.30

1.3

Benzonitrile

6.30

0.12

1.6

Nitrobenzene

7.58

0.26

1.9

Anisole

8.04

0.34

2.1

Methylbenzoate

8.55

0.30

2.1

Toluene

12.91

0.58

2.7

Phthalide

4.50

-0.178

-

Using the function equation, the following log Pow value is calculated for the test substance:

log Pow = 1.32

log P ow = 1,6 * log k '+ 1,60

log Pow = 1,32

Correlation coefficient r = 0,9737

Applicant's summary and conclusion