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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature. Unreliable Test Institute (IBT)

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1970

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
5 rabbits, after application of TS rabbits were wrapped, exposure time 4 hrs, symptoms were recorded, gross autopsy
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Phthalic anhydride
- Purity: no data
- Other: melting point: 130.8 °C

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Details on dermal exposure:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

TEST MATERIAL
- Concentration (if solution): 50% suspension
- Constant volume or concentration used: yes



Duration of exposure:
4 hours
Doses:
10000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Mortality:
no death occurred
Clinical signs:
No signs of systemic intoxication were observed, local signs observed were mild erythema and oedema on removal of the wrappings. Recovery
occurred at the same day.
Body weight:
no data
Gross pathology:
Gross autopsy revealed no significant findings.

Any other information on results incl. tables

Unreliable test institute (IBT).

Applicant's summary and conclusion