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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Between 3 October 1996 and 13 November 1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Commission Regulation (EC) No 440/2008 of 30 May 2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
0.001 g/L
Temp.:
20 °C
pH:
> 5.2 - < 5.9
Remarks on result:
other: Range - 2.3 x l0-4 to 9.4 x 10-4 g/L

Results

The preliminary estimate of the water solubility of OS 114461 was determined to be less than 1 mg/l.

The concentration (g/l) of each component within the test material in the sample solutions is shown in the following table:

  Water solubility
 Sample number  Time shaken (approx. 30°C (hours))  Time equilibrated at 20°C (hours) Concentration (g/L)  Solution pH
 1  24  24  0.00053 5.9
 2 48   24  0.00073 5.2 
 3 72  24  0.00094   5.3
 4  96  24 0.00039  5.6
 5  120  24 0.00023  5.5
 6  144  24 0.00043  5.3

Mean concentration = 5.4 10-4g/ l at 20.0 ± 0.5°C

  Range 2.3 10-4g/ l to 9.4 10-4g/ l

 

 

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)The water solubility of the test material has been determined to be 5.4E-04 g/L of solution at 20.0 +/- 0.5 deg C.
Executive summary:

GUIDELINE

The water solubility was investigated in a GLP-compliant study using the flask method according to the EU A.6 . The experiment is deemed valid, conclusive and thus suitable for assessment without restrictions.

 

METHODS

 

Based on the preliminary result, mixtures of 0.1060, 0.1226, 0.1086, 0.135, 0.1171 or 0.11483 g test item and 200 mL glass double-distilled water were added to six separate flasks. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C and, after standing at 20 °C for a period of no less than 24h, the contents of the flasks were filtered.

RESULTS

The water solubility of the test material has been determined to be 5.4E-04 g/L of solution at 20.0 +/- 0.5 deg C.

 

Description of key information

The water solubility of the test material has been determined to be 5.4E-04 g/L of solution at 20.0 +/- 0.5 deg C (EU Method A.6).

Key value for chemical safety assessment

Water solubility:
0.001 g/L
at the temperature of:
20 °C

Additional information

GUIDELINE

The water solubility was investigated in a GLP-compliant study using the flask method according to the EU A.6. The experiment is deemed valid, conclusive and thus suitable for assessment without restrictions.

 

METHODS

Based on the preliminary result, mixtures of 0.1060, 0.1226, 0.1086, 0.135, 0.1171 or 0.11483 g test item and 200 mL glass double-distilled water were added to six separate flasks. After addition of glass double-distilled water to the flasks, they were shaken at approximately 30 °C and, after standing at 20 °C for a period of no less than 24h, the contents of the flasks were filtered.

RESULTS

The water solubility of the test material has been determined to be 5.4E-04 g/L of solution at 20.0 +/- 0.5 deg C.