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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Between 3 October 1996 and 13 November 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 3.42
pH:
7.1
Remarks on result:
other: Temperature not reported.
Details on results:
The partition coefficient determined by extrapolation from the calibration curve indicates a logPow value of >3.42 by using HPLC method.

The retention times, capacity factors and log10Pow values determined for the sample are shown in the following table:

 
Table

 

 

Peak

Injection

Retention Time (mins)

Capacity Factor(k)

Log10k

Log10Pow

Mean Log 10 Pow

% Area

1

1

5.756

0.929

-0.032

3.42

3.42

0.7

2

5.768

0.933

-0.0301

3.43

2

1

6.897

1.311

0.118

4.2

4.2

37

2

6.909

1.315

0.119

4.2

3

1

8.408

1.818

0.26

4.93

4.94

40.3

2

8.425

1.823

0.261

4.94

4

1

9.23

2.093

0.321

5.25

5.26

0.7

2

9.25

2.1

0.322

5.26

5

1

10.209

2.421

0.384

5.58

5.59

5.8

2

10.233

2.429

0.385

5.89

6

1

10.519

2.525

0.402

5.68

5.68

5.3

2

10.544

2.534

0.404

5.68

7

1

11.47

2.844

0.454

5.95

5.95

1.6

2

11.497

2.853

0.455

5.95

8

1

14.195

3.757

0.575

>6.2

>6.2

8.5

2

14.234

3.77

0.576

>6.2

9

1

14.676

3.918

0.593

>6.2

>6.2

8.5

2

14.719

3.933

0.595

>6.2

10

1

18.435

5.178

0.714

>6.2

>6.2

8.5

2

18.493

5.197

0.716

>6.2

11

1

19.078

5.393

0.732

>6.2

>6.2

8.5

2

191.141

5.415

0.734

>6.2

12

1

24.345

7.157

0.855

>6.2

>6.2

8.5

2

24.409

7.18

0.856

>6.2

Overall log10Pow: >3.42

Partition coefficient: >2650

Conclusions:
The partition coefficient determined by extrapolation from the calibration curve indicates a logPow value of >3.42 by using HPLC method.
Executive summary:

Method

The determination was carried out using the HPLC Method, Method A8 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC)

 

Result

The partition coefficient of the test material has been determined to be greater than 2.65E03, log10 Pow >3.42.

Description of key information

The partition coefficient determined by extrapolation from the calibration curve indicates a log Pow value of >3.42 by using HPLC method (EU method A.8).

Key value for chemical safety assessment

Log Kow (Log Pow):
3.42

Additional information

Method

The determination was carried out using the HPLC Method, Method A8 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC)

 

Result

The partition coefficient of the test material has been determined to be greater than 2.65E03, log10 Pow >3.42.