Registration Dossier
Registration Dossier
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EC number: 206-117-5 | CAS number: 302-17-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative review article and database.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- CONCISE INTERNATIONAL CHEMICAL ASSESSMENT DOCUMENT NO. 25; CHLORAL HYDRATE
- Author:
- World Health Organisation
- Year:
- 2 000
- Bibliographic source:
- International Programme on Chemical Safety, Environmental Health Criteria (EHS)
- Reference Type:
- other: Authoritative database
- Title:
- Acute inhalation toxicity value for CAS 302-17-0
- Author:
- IFA-Gestis
- Year:
- 2 018
- Bibliographic source:
- Gestis substance database
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity was determined for the test substance 2,2,2-trichloroethane-1,1-diol (Chloral hydrate) in mice following 6 hour exposure.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2,2-trichloroethane-1,1-diol
- EC Number:
- 206-117-5
- EC Name:
- 2,2,2-trichloroethane-1,1-diol
- Cas Number:
- 302-17-0
- Molecular formula:
- C2H3Cl3O2
- IUPAC Name:
- 2,2,2-trichloroethane-1,1-diol
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- 100 ppm (20mg/Kg bw)
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 603 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: Following cessation of exposure, the animals regained consciousness.
- Mortality:
- no mortality observed
- Clinical signs:
- other: Clinical Signs observed were Deep narcosis, following effects were induced in the lung: formation of vacuoles in the Clara cells, scaling off of the epithelium and pulmonary edema (increase of the lung weight by a factor of 1.5).
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- Following cessation of exposure, the animals regained consciousness.
Applicant's summary and conclusion
- Interpretation of results:
- other: not toxic
- Conclusions:
- The LC50 for the given test material Chloral Hydrate is found to be >100 ppm (>603mg/m3).
- Executive summary:
Mice were exposed to the test material chloral hydrate at a concentration of 100 ppm ( 603mg/m3) for 6 hours.
Inhalation exposure resulted in deep narcosis but following cessation of exposure, the animals regained consciousness. The following effects were induced in the lung: formation of vacuoles in the Clara cells, scaling off of the epithelium and pulmonary edema (increase of the lung weight by a factor of 1.5).
Acute inhalation study conducted shows that the LC50 for the given test material Chloral Hydrate is found to be >100 ppm (>603 mg/m3).
This value indicates thta the substance is not toxic via inhalation route and thus considered as Not classified for Acute toxicity inhalataion as per CLP classification criteria.
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