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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Acute, single exposure
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Primary source from peer-reviewed journal.
Handbook source from United Nations CICAD report, Concise International Chemical Assessment Document 25, 2000
The substance carries a harmonised classification for acute oral toxicity

Data source

Reference
Reference Type:
publication
Title:
Fate of 2,2,2-trichloroacetaldehyde, (chloral hydrate) produced during trichloroethylene, oxidation by methanotrophs
Author:
Newman LM, Wackett LP
Year:
1991
Bibliographic source:
Applied and environmental microbiology, 57:2399–2402

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
Mice
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,2-trichloroethane-1,1-diol
EC Number:
206-117-5
EC Name:
2,2,2-trichloroethane-1,1-diol
Cas Number:
302-17-0
Molecular formula:
C2H3Cl3O2
IUPAC Name:
2,2,2-trichloroethane-1,1-diol
Test material form:
solid: granular

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
300, 600, 900, 1200, 1500, and 1800 mg/kg body weight
No. of animals per sex per dose:
8 male, 8 female
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD0
Effect level:
ca. 900 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 1 265 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 1 442 mg/kg bw
Based on:
test mat.
Key result
Sex:
male/female
Dose descriptor:
discriminating dose
Effect level:
< 300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Sedation observed at all dose levels and considered to be an adverse effect
Mortality:
Yes, at higher dose groups and all within 24 hours of administration
No mortality at 900 mg/kg or lower
Clinical signs:
Yes; lethagy and sedation observed within minutes of administration
Body weight:
Not specified
Gross pathology:
None reported
Other findings:
Sedation occured at 300 mg/kg and higher, with effects observed within minutes of administration.

Any other information on results incl. tables

The mice became sedated at 300 mg/kg body weight. At 600 and 900 mg/kg the animals became lethargic and exhibited loss of righting reflex.

Respiration was markedly inhibited at 1200, 1500, and 1800 mg/kg.

Inhibition of respiration appeared to be the immediate cause of death

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
Other acute oral studies are cited in the UN CICAD report, with Rat LD50 considered to be 480 mg/kg.
In view of the harmonised classification, further testing is not justified.