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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Justification for type of information:
Experimental test result performed using standard methods
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The solubility determination of test substance 2,2,2–trichloroethane-1,1-diol (CAS No. 302-17-0) in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF).
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid
Key result
Medium:
acetone
Solubility:
> 1 000 g/L
Temp.:
30 °C
Key result
Medium:
acetonitrile
Solubility:
> 1 000 g/L
Temp.:
30 °C
Key result
Medium:
methanol
Solubility:
> 1 000 g/L
Temp.:
30 °C
Key result
Medium:
toluene
Solubility:
> 1 000 g/L
Temp.:
30 °C
Key result
Medium:
dimethylformamide
Solubility:
> 1 000 mg/L
Temp.:
30 °C
Key result
Medium:
ethanol
Solubility:
>= 200 - <= 1 000 g/L
Temp.:
30 °C
Test substance stable:
not determined

The solubility range of the substance 2,2,2–trichloroethane-1,1-diol(CAS No. 302-17-0)in acetone, acetonitrile, methanol, toluene and DMF was found to be greater than 1000 g/l. whereas the solubility range of the substance was found to be in the range of 200 – 1000 g/l in case of ethanol respectively.

Conclusions:
The solubility range of the substance 2,2,2–trichloroethane-1,1-diol(CAS No. 302-17-0)in acetone, acetonitrile, methanol, toluene and DMF was found to be greater than 1000 g/l. whereas the solubility range of the substance was found to be in the range of 200 – 1000 g/l in case of ethanol respectively.
Executive summary:

The solubility determination of test substance2,2,2–trichloroethane-1,1-diol(CAS No. 302-17-0) in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetone, acetonitrile, methanol, toluene and DMF was found to be greater than 1000 g/l whereas the solubility value in ethanol was found to be in the range of 200 – 1000 g/l, respectively at 30 °C.

Description of key information

The solubility determination of test substance2,2,2–trichloroethane-1,1-diol(CAS No. 302-17-0) in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetone, acetonitrile, methanol, toluene and DMF was found to be greater than 1000 g/l whereas the solubility value in ethanol was found to be in the range of 200 – 1000 g/l, respectively at 30 °C.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
1 000 g/L

Additional information

The solubility determination of test substance2,2,2–trichloroethane-1,1-diol(CAS No. 302-17-0) in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetone, acetonitrile, methanol, toluene and DMF was found to be greater than 1000 g/l whereas the solubility value in ethanol was found to be in the range of 200 – 1000 g/l, respectively at 30 °C.