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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Acute toxicity
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Although cited in several government and non-governmental publications, no primary source has been found
The oldest reference is found in 'Agrochemicals Handbook, Hartley and Kidd, eds.,Royal Soc. of Chemistry, 1983-86'
There is no justification to perform further animal tests.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Guideline not specified.
Performed prior to 1983
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,2-trichloroethane-1,1-diol
EC Number:
206-117-5
EC Name:
2,2,2-trichloroethane-1,1-diol
Cas Number:
302-17-0
Molecular formula:
C2H3Cl3O2
IUPAC Name:
2,2,2-trichloroethane-1,1-diol
Test material form:
solid: granular

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 3 030 mg/kg bw
Based on:
test mat.
Mortality:
Not specified
Clinical signs:
other: Not specified
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Although no primary reference was located, many reliable data sets have used this figure for acute dermal LD50
There is no justification to perform further animal tests.