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Diss Factsheets

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

Additional information

Appearance

5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is a yellow powder.

 

Melting Point

Key Study:

In an EU Method A.1 study, not conducted according to GLP, the melting temperature of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is 164.5°C (Intertek Pharmaceutical Services Manchester, 2014).

 

Boiling Point

Key Study:

In an EU Method A.2 study, not conducted according to GLP, the boiling temperature of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione could not be measured due to possible thermal decomposition (Intertek Pharmaceutical Services Manchester, 2014).

 

Density

Key Study:

In an EU Method A.3 study, not conducted according to GLP, the relative density of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is 2.01 +/- 0.01 at 20°C +/- 0.5°C (Intertek Pharmaceutical Services Manchester, 2014).

 

Particle Size

Key Study:

In an OECD 110 study, not conducted according to GLP, the median particle size of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is 6.456 µm, with a mass median aerodynamic diameter of 4.554 µm. The particle size distribution is 10% of the substance <2.719 µm, 50% of the substance <6.456 µm and 90% of the substance <11.816 µm (Intertek Pharmaceutical Services Manchester, 2014).

 

Vapour Pressure

Key Study:

In an EU Method A.4 study, using the Grain-Watson Correction for Solids and accounting for the enthalpy of melting and a theoretical boiling point, the vapour pressure of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is estimated to be 0.000041 Pa at 25°C (Intertek Pharmaceutical Services Manchester, 2014).

 

Partition Coefficient

Key Study:

In a study conducted according to GLP, the partition coefficient (log Pow) of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione estimated based on the ratio of n-octanol solubility and water solubility is 1.46 at 25 ± 1°C (Intertek Pharmaceutical Services Manchester, 2016).

 

Water Solubility

Key Study:

In an EU Method A.6 (shake flask) study, conducted according to GLP, the water solubility of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is 167 mg/L at 25°C ± 1°C (Intertek Pharmaceutical Services Manchester, 2016).

 

Surface Tension

Key Study:

In an EU Method A.5 (plate method), not conducted according to GLP, the mean surface tension of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is 65 mN/m at 25 ± 0.5°C over a measured concentration range of 322 to 434 mg/L (Intertek Pharmaceutical Services Manchester, 2014).

 

Flash Point

A flash point study is applicable for liquid substances, while a flammability study is applicable for solids. 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is a solid, therefore the flammability study is more applicable for testing and the flash point study is waived.

 

Auto Flammability

Key Study:

In an EU Method A.16 study, not conducted according to GLP, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione did not auto ignite (Intertek Pharmaceutical Services Manchester, 2014).

 

Flammability

Key Study:

In an EU Method A.10 study, not conducted according to GLP, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is not flammable (Intertek Pharmaceutical Services Manchester, 2014).

 

Explosivity

Key Study:

Based on a comprehensive examination of the structural formula, according to guidance in the UN Transport of Dangerous Goods, Manual of Tests and Criteria, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione does not exhibit explosive properties and is not considered capable of rapid gas or heat release (Intertek Pharmaceutical Services Manchester, 2014). Conduct of an explosivity study according to EU Method A.14 therefore is waived.

 

Oxidising Properties

Key Study:

In an EU Method A.17 study, not conducted according to GLP, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is not oxidising (Intertek Pharmaceutical Services Manchester, 2014).