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EC number: 203-214-4 | CAS number: 104-57-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-02-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Noack Laboratorien GmbH, Käthe-Paulus-Str. 1, 31157 Sarstedt, Germany.
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.79
- Temp.:
- 21.9 °C
- Remarks on result:
- other: Mean value of 2 measurements; no pH value was reported but the mobile phase is neutral.
- Conclusions:
- The partition coefficient of the test substance was determined to be 1.79 at 21.9 °C.
- Executive summary:
The partition coefficient of the test substance was determined according to OECD Guideline 117 and EU Method A.8 by the HPLC method. The test was performed with a concentration of 10 mg/L of the test item in 35% acetonitrile : 65 % HPLC water. Samples of the test item were analysed via HPLC on a C18 column with diode array detection. Calibration was performed using seven reference items with known log Pow values. A mean log Pow value of 1.79 at 21.9 °C was determined for the test substance.
Reference
Table. 1: Summarozed Results of the Partition Coefficient
Log Pow |
||
1stCalibration |
2ndCalibration |
Mean |
1.79±0.03 1.72 to 1.87 (95% CI) |
1.79±0.03 1.72 to 1.87 (95% CI) |
1.79 |
Pow: Partition Coefficient (n-octanol/water)
CI: Conficence interval
Description of key information
Partition coefficient of the test item was determined to be log Pow = 1.79 at 21.9 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.79
- at the temperature of:
- 21.9 °C
Additional information
The octanol-water partition coefficient of the substance was determined according to OECD 117 by the HPLC method. A log Pow value of 1.79 at 21.9 °C was determined for the test substance and is considered as reliable.
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