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Diss Factsheets

Physical & Chemical properties

Boiling point

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Administrative data

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Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015-10-30 to 2016-01-06
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
GLP compliance:
no
Remarks:
The study was conducted under supervision of a quality assurance unit which had ensured e.g instrumentation validation, reagent/materials certification, analyst certification and providing standard operating procedures.
Other quality assurance:
other: SOP-LA-021 Boiling Point by DSC
Type of method:
differential scanning calorimetry
Key result
Boiling pt.:
>= 201 - <= 203 °C
Atm. press.:
1 013 hPa
Decomposition:
no
Conclusions:
The test item has a boiling point range of 201 to 203 °C corrected to normal atmospheric pressure (1013 hPa) as determined by differential scanning calorimetry.
Executive summary:

The test item has a boiling point range of 201 to 203 °C corrected to normal atmospheric pressure (1013 hPa) as determined by differential scanning calorimetry according to Regulation EC no. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: authoritative secondary source.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Secondary literature source. No data about the method was available.
GLP compliance:
no
Key result
Boiling pt.:
203 °C
Atm. press.:
1 013.25 hPa
Decomposition:
no
Conclusions:
The boiling point was reported to be 203 °C at 1013.25 hPa.
Executive summary:

The publication of Lecat (1943) was regarded as reliable literature source and was taken into account in this weight of evidence approach. In this publication a boiling point of 203 °C at 1013.25 hPa was reported for the test item.

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: authoritative secondary source.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Secondary literature source. No data about the method was available.
GLP compliance:
no
Key result
Boiling pt.:
203 °C
Atm. press.:
1 013.25 hPa
Decomposition:
no
Remarks on result:
other: Actually, the ambient pressure is not reported.
Conclusions:
The GESTIS database reported a boiling point of 203 °C at 1013.25 hPa for the test item.
Executive summary:

The authoritative database from the Institute for Occupational Safety and Health of the German Social Accident Insurance (GESTIS database) is regarded as reliable literature source and was taken into account in this weight of evidence approach. The GESTIS database reported a boiling point of 203 °C at 1013.25 hPa for the test item.

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: authoritative secondary source.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Secondary literature source. No data about the method was available.
GLP compliance:
no
Key result
Boiling pt.:
202.3 °C
Atm. press.:
101.3 kPa
Decomposition:
no
Conclusions:
The boiling point was reported to be 202.3 °C at 101.3 kPa.
Executive summary:

The authoritative GSBL database is regarded as reliable literature source and was taken in to account in this weight of evidence approach. The database reported a boiling point of 202.3 °C at 101.3 kPa for the test item.

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: authoritative secondary source.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Secondary literature source. No data about the method was available.
GLP compliance:
no
Key result
Boiling pt.:
202 °C
Atm. press.:
1 013.25 hPa
Decomposition:
no
Conclusions:
The boiling point was reported to be 202 °C at 1013.25 hPa.
Executive summary:

The publication of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is regarded as reliable literature source and was taken into account in this weight of evidence approach. The JECFA reported a boiling point of 202 °C at 1013.25 hPa for the test item.

Description of key information

The boiling point was determined to be 202 °C at 1013.25 hPa.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
202 °C

Additional information

Key study:

The test item has a boiling point range of 201 to 203 °C corrected to normal atmospheric pressure (1013 hPa) as determined by differential scanning calorimetry according to Regulation EC no. 440/2008 Method A.2. and OECD Test Guideline 103 (1995).

Weight of evidance studies:

Additionally a literature review was conducted. In a weight of evidence approach the literature values were evaluated. Lecat (1943) and the GESTIS database reported a boiling point for the test substance of 203 °C at 1013.25 hPa, respectively. Furthermore, the GSBL database reported a boiling point of 202.3 °C and the JECFA reported a boiling point of 202 °C at atmospheric pressure. 

The literatur review supports the results of the key study, and therefore 203 °C at 1013.25 °C was chosen as key value for chemical safety assessment as it was from the most reliable literature source.