Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-214-4 | CAS number: 104-57-4
An acute oral toxicity study was carried out to assess the potential toxicity of the test substance after a single oral administration. The acute toxic class method was followed. Three dose groups of three females each were utilized as follows: Group 1 (Step 1): 2000 mg/kg bw of the test substance Groups 2 and 3 (Steps 2 and 3): 300 mg/kg bw of the test substance Step 1: A dose of 2000 mg/kg bw was administered and then, there were two dead animals at 2000 mg/kg bw (Step 1). Steps 2-3: There were two dead animals (Step 1), thus a second dose of 300 mg/kg bw was administered. Then, there was no mortality (Step 2). A third dose of 300 mg/kg bw was administered (Step 3). All animals were monitored for clinical signs and body weight changes during the 14-day observation period after administration. They were subjected to a gross necropsy at the end of the observation period. There were no deaths of animals at 300 mg/kg bw. No test substance-related effects were observed in clinical signs, body weight data or necropsy findings in any animal at 300 mg/kg bw. Based on the result of the acute oral toxicity study in Sprague-Dawley rats, the test substance, was classified as Category 4 according to the GHS classification and the median lethal dose derived was: LD50 = 1000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again