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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
The toxicology of some glycols and derivatives.
Author:
Laug E, Calvery HO, Morris HJ, Woodward G
Year:
1939
Bibliographic source:
Journal of Industrial Hygiene and Toxicology 21: 173 - 201

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-oxydiethanol
EC Number:
203-872-2
EC Name:
2,2'-oxydiethanol
Cas Number:
111-46-6
Molecular formula:
C4H10O3
IUPAC Name:
2-(2-hydroxyethoxy)ethan-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
11160, 12555, 13950, 16740, 19530, 20925, 22320 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
The animals were sacrificed after 5 days of observation.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
16 500 mg/kg bw
Mortality:
yes
Clinical signs:
other: Thirst, diuresis, ruffled coat and refusal of food were reported. After the first 2 to 3 days there was cessation of urine excretion with heavy proteinuria. Prostration, dyspnea, bloated appearance, coma, and pronounced lowering of body temperature were r
Gross pathology:
Histopathology:
- There was extensive degeneration of the renal cortex with vacuolar (hydropic) degeneration of the convoluted tubules.
- In the liver there was widespread diffuse hydropic degeneration of the central of lobules.
- The lung of some animals showed congestion, edema and focal interstitial pneumonia and hemorrhage in some cases.
- The spleen in many cases showed excessive phagocytosis of blood pigment.

Applicant's summary and conclusion