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EC number: 203-872-2 | CAS number: 111-46-6
Summary table - Induction of Micronuclei in bone marrow cells - single intraperitoneal administration
Micronuclei in PCE
Vehicle controlpurified water
Test substance500 mg/kg bw.
Test substance1 000 mg/kg bw.
Test substance2 000 mg/kg bw.
Positive controlcyclophosphamide 20 mg/kg bw.
Positive controlvincristine sulfate0.15 mg/kg bw.
= polychromatic erythrocytes
= normochromatic erythrocytes
= body weight
= sum of small and large micronuclei
= large micronuclei (indication for spindle poison effect)
= number of NCEs observed when scoring 10 000 PCEs (indication for target organ toxicity)
= p ≤ 0.05
= p ≤ 0.01
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