Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-872-2
CAS no.:
111-46-6
Index number:
603-140-00-6
Molecular formula:
C4H10O3
SMILES:
OCCOCCO
InChI:
InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
4
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is harmful if swallowed.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may cause damage to organs through prolonged or repeated exposure.

Breakdown of all 5709 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
STOT RE 2 H373
STOT SE 3 H336
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 3 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

This substance is used in the following products: washing & cleaning products, anti-freeze products, biocides (e.g. disinfectants, pest control products), coating products, non-metal-surface treatment products and inks and toners.

Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, non-industrial spraying and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, for thermoplastic manufacture, of substances in closed systems with minimal release and as an intermediate step in further manufacturing of another substance (use of intermediates).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • REACHLaw Ltd, Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland

Substance names and other identifiers

2,2' -oxybisethanol
C&L Inventory
2,2' -oxybisethanol; diethylene glycol
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
2,2'-oxydiethanol
EC Inventory, REACH pre-registration, Cosmetic Products Regulation, Annex II - Prohibited Substances
2,2'-oxydiethanol
Substance Evaluation - CoRAP, REACH pre-registration, Cosmetic Products Regulation, Annex II - Prohibited Substances
2,2'-oxydiethanol Diethylene glycol
Cosmetic Products Regulation, Annex III - Restricted Substances
Bis (2-hydroxyethyl) ether
Food Contact Regenerated Cellulose Directive - Authorised Substances
DEG
Cosmetic Products Regulation, Annex III - Restricted Substances
Diethylene glycol
C&L Inventory, Other
diethyleneglycol
FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use,
2,2' -oksibisetanol (hr)
C&L Inventory
2,2' -Oksibisetanoli (fi)
C&L Inventory
2,2' -oxibisetanol (ro)
C&L Inventory
2,2' -oxietanol (sv)
C&L Inventory
2,2' -oxydietanol (sk)
C&L Inventory
2,2'-oksibisetanoldietilenglikolis (lt)
C&L Inventory
2,2'-oksidietanol (sl)
C&L Inventory
2,2'-oksydietanol (no)
C&L Inventory
2,2'-ossidietanolo (it)
C&L Inventory
2,2'-oxidietanol (es)
C&L Inventory
2,2'-oxidietanol (pt)
C&L Inventory
2,2'-oxybiséthanol; diéthylène glycol (fr)
C&L Inventory
2,2'-oxydiethan-1-ol (cs)
C&L Inventory
2,2'-oxydiethanol (da)
C&L Inventory
2,2'-Oxydiethanol (de)
C&L Inventory
2,2'-oxydiethanol (nl)
C&L Inventory
2,2'-οξυδισαιθανόλη (el)
C&L Inventory
2,2'-оксибисетанол (bg)
C&L Inventory
2,2`-oksybisetanol (pl)
C&L Inventory
2,2’-oksibis-etanols (lv)
C&L Inventory
2,2’-oksübisetanool (et)
C&L Inventory
2,2’-oxibiszetanol (hu)
C&L Inventory
2-idrossietil etere (it)
C&L Inventory
diethylenglycol (da)
C&L Inventory
diethylenglykol (cs)
C&L Inventory
Diethylenglykol (de)
C&L Inventory
dietilen glicol (ro)
C&L Inventory
dietilen glicole (it)
C&L Inventory
dietilen-glikol (hr)
C&L Inventory
dietilenglicol (pt)
C&L Inventory
dietilenglikolis (lt)
C&L Inventory
dietilén-glikol (hu)
C&L Inventory
dietilēnglikols (lv)
C&L Inventory
dietlenglikol (sl)
C&L Inventory
dietylenglykol (no)
C&L Inventory
dietylenglykol (sv)
C&L Inventory
Dietylieeniglykoli (fi)
C&L Inventory
dietylénglykol (sk)
C&L Inventory
dietüleenglükool (et)
C&L Inventory
diéthylène glycol (fr)
C&L Inventory
glikol dietylenowy (pl)
C&L Inventory
διαιθυλενογλυκόλη (el)
C&L Inventory
диетилен гликол (bg)
C&L Inventory
Ethanol, 2,2'-oxybis-
Other
(2-hydroxyethoxy) ethan-2-ol
C&L Inventory, Registration dossier
(2-hydroxyethoxy)ethan-2-ol
C&L Inventory, Registration dossier
(2-hydroxyethoxy)ethan-2-ol2,2'-Oxydiethanol2,2-oxydiethanol2-(2-hydroxyethoxy)ethanolDEGDi-ethylene GlycolDiethylene GlycolDiethylene Glycol (DEG)DiethyleneglycolDiethylenglycolDiethylenglykol
Registration dossier
2,2' -oxybisethanol
C&L Inventory
2,2''-oxydiethanol
C&L Inventory
2,2'- ossidietanolo
C&L Inventory
2,2'-DIHYDROXYDIETHYL ETHER
C&L Inventory
2,2'-oxybisenthanol
C&L Inventory
2,2'-Oxybisethanol
C&L Inventory
2,2'-oxydiethano
C&L Inventory
2,2'-OXYDIETHANOL
C&L Inventory, Registration dossier
2,2'-Oxydiethanol
C&L Inventory, Registration dossier
2,2'-oxydiethanol; diethylene-glycol
C&L Inventory
2,2'Oxybisethanol
C&L Inventory
2,2-Oxybisethanol
Registration dossier
2,2-Oxydiethanol
C&L Inventory, Registration dossier
2,2`-oxybisethanol
C&L Inventory
2,2’-Oxybisethanol
C&L Inventory
2,2’-Oxybisethanol
C&L Inventory, Registration dossier
2,2’-oxydiethanol
C&L Inventory
2,2′-Oxydiethanol
C&L Inventory
2-(2 hydroxyethoxy)ethanol
C&L Inventory
2-(2-butoxyethoxy)ethanol diethylene glycol monobutyl ether
C&L Inventory
2-(2-Hydroxyethoxy)ethan-1-ol
C&L Inventory, Registration dossier, Other
2-(2-hydroxyethoxy)ethan-1-ol)
Registration dossier
2-(2-Hydroxyethoxy)ethanol
C&L Inventory, Registration dossier
2-(2-hydroxyethoxy)ethanol 
C&L Inventory
2.2'-Oxybisethanol
C&L Inventory
3-ossa-1,5-pentandiolo
C&L Inventory
3-oxopentan-1,5-diol 1.3
C&L Inventory
Agent T294
Registration dossier
Bis(2-hydroxyethyl) ether
C&L Inventory
Bis(2-hydroxyethyl)ether
C&L Inventory
CH2OHCH2OCH2CH2OH
C&L Inventory
DEG
Registration dossier
Di(ethylenglicol)
C&L Inventory
Di-ethylene Glycol
Registration dossier
diethylen glycol
C&L Inventory
DIETHYLENE GLYCOL
C&L Inventory, Registration dossier
Diethylene Glycol
C&L Inventory, Registration dossier
Diethylene Glycol (DEG)
Registration dossier
DIETHYLENE-GLYCOL
C&L Inventory
Diethyleneglycol
Registration dossier
Diethylenglycol
C&L Inventory
Diethylenglycol
C&L Inventory, Registration dossier
Diethylenglykol
C&L Inventory
Diethylenglykol
Registration dossier
ethan-1,2-diol
C&L Inventory
Ethanol, 2,2'-oxybis-
C&L Inventory
Ethanol, 2,2'-oxybis-
C&L Inventory
glycol ether
C&L Inventory
N.A.
C&L Inventory
Reaction mass of 1309-37-1 and 1317-65-3 and 20344-49-4 and 61791-23-9
C&L Inventory
2,2'-Oxybis[ethano]
Registration dossier
2,2'-Oxybis[ethanol]
Registration dossier
2,2'-Oxydiethanol
Registration dossier
2,2'-Oxyethanol
Registration dossier
2- hydroxyethoxy)ethan-2-ol
Registration dossier
2-(2-Hydroxyethoxy)ethanol
Registration dossier
3-Oxapentamethylene-1,5-diol
Registration dossier
3-Oxapentane-1,5-diol
Registration dossier
Agent T294
Registration dossier
Bis(2-hydroxyethyl) ether
Registration dossier
Bis(2-hydroxyethyl)ether
Registration dossier
Bis(β-hydroxyethyl) ether
Registration dossier
Bis(β-hydroxyethyl)ether
Registration dossier
DEG
Registration dossier
Di Ethylene Glycol
Registration dossier
Di ethyleneglycol
Registration dossier
Dicol
Registration dossier
Diethylene glcyol
Registration dossier
Diethylene Glycol
Registration dossier
Diethylene glycol (DEG)
Registration dossier
DiethyleneGlycolTech
Registration dossier
Diethylenglykol
Registration dossier
Dietilen glicole
C&L Inventory
Dietylene glycol
Registration dossier
Digenos
Registration dossier
Diglycol
Registration dossier
diglycol glycol
Registration dossier
Digol
Registration dossier
Dihydroxyethyl ether
Registration dossier
Ethanol, 2,2'-oxybis-
Registration dossier
Ethanol, 2,2'-oxybis- (9CI)
Registration dossier
Ethylene diglycol
Registration dossier
Glicole Dietilenico
Registration dossier
glikol dietylenowy
Registration dossier
Glycol ethyl ether
Registration dossier
Not applicable
Registration dossier
β,β'-Dihydroxydiethyl ether
Registration dossier
2,2'-oxydiethanol
REACH pre-registration
Diethylene Glycol
REACH pre-registration
Ethanol, 2,2'-oxybis-
REACH pre-registration
111-46-6
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex III - Restricted Substances, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, , Food Contact Regenerated Cellulose Directive - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
2126734-27-6
CAS number
Other
2126734-27-6
Deleted CAS number
Other
4669-26-5
CAS number
Other
4669-26-5
Deleted CAS number
Other
603-140-00-6
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Data not provided by the registrant

Melting/freezing point

Data not provided by the registrant

Boiling point

Data not provided by the registrant

Density

Data not provided by the registrant

Vapour pressure

Data not provided by the registrant

Partition coefficient

Data not provided by the registrant

Water solubility

Data not provided by the registrant

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Data not provided by the registrant

Flash point

Data not provided by the registrant

Auto flammability

Data not provided by the registrant

Flammability

Data not provided by the registrant

Explosiveness

Data not provided by the registrant

Oxidising

Data not provided by the registrant

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Data not provided by the registrant

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Data not provided by the registrant

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Data not provided by the registrant

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Data not provided by the registrant

Short–term toxicity to fish

Data not provided by the registrant

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Data not provided by the registrant

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Data not provided by the registrant

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Data not provided by the registrant

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Data not provided by the registrant

Acute toxicity

Data not provided by the registrant

Irritation / corrosion

Data not provided by the registrant

Sensitisation

Data not provided by the registrant

Repeated dose toxicity

Data not provided by the registrant

Genetic toxicity

Data not provided by the registrant

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Data not provided by the registrant

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant