2,2'-oxydiethanol

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference

Reference Type:

publication

Title:

A simple dermal absorption model: Derivation and application

Author:

ten Berge, Wil

Year:

2009

Bibliographic source:

Chemosphere 75, 1440-1445

Materials and methods

Type of study / information:

Derivation of a QSAR

Principles of method if other than guideline:

This paper describes the development of two QSARs (= Quantitative Activity Structural Relationships), one for the estimation of the skin permeation coefficient through intact skin from aqueous solution and the second for the estimation of the stratum corneum/water partition coefficient. Measured data on human skin absorption from aqueous solution in vitro and on human stratum corneum/water partition coefficients in vitro were used for establishing the QSARs.

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-oxydiethanol

EC Number:

203-872-2

EC Name:

2,2'-oxydiethanol

Cas Number:

111-46-6

Molecular formula:

C4H10O3

IUPAC Name:

2-(2-hydroxyethoxy)ethan-1-ol