Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
publication
Title:
A simple dermal absorption model: Derivation and application
Author:
ten Berge, Wil
Year:
2009
Bibliographic source:
Chemosphere 75, 1440-1445

Materials and methods

Type of study / information:
Derivation of a QSAR
Principles of method if other than guideline:
This paper describes the development of two QSARs (= Quantitative Activity Structural Relationships), one for the estimation of the skin permeation coefficient through intact skin from aqueous solution and the second for the estimation of the stratum corneum/water partition coefficient. Measured data on human skin absorption from aqueous solution in vitro and on human stratum corneum/water partition coefficients in vitro were used for establishing the QSARs.

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-oxydiethanol
EC Number:
203-872-2
EC Name:
2,2'-oxydiethanol
Cas Number:
111-46-6
Molecular formula:
C4H10O3
IUPAC Name:
2,2'-oxydiethanol

Results and discussion

Applicant's summary and conclusion