Registration Dossier
Registration Dossier
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EC number: 203-872-2 | CAS number: 111-46-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- publication
- Title:
- A simple dermal absorption model: Derivation and application
- Author:
- ten Berge, Wil
- Year:
- 2 009
- Bibliographic source:
- Chemosphere 75, 1440-1445
Materials and methods
- Type of study / information:
- Derivation of a QSAR
- Principles of method if other than guideline:
- This paper describes the development of two QSARs (= Quantitative Activity Structural Relationships), one for the estimation of the skin permeation coefficient through intact skin from aqueous solution and the second for the estimation of the stratum corneum/water partition coefficient. Measured data on human skin absorption from aqueous solution in vitro and on human stratum corneum/water partition coefficients in vitro were used for establishing the QSARs.
Test material
- Reference substance name:
- 2,2'-oxydiethanol
- EC Number:
- 203-872-2
- EC Name:
- 2,2'-oxydiethanol
- Cas Number:
- 111-46-6
- Molecular formula:
- C4H10O3
- IUPAC Name:
- 2-(2-hydroxyethoxy)ethan-1-ol
Constituent 1
Results and discussion
Applicant's summary and conclusion
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