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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source; original study report not available.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1970
Report date:
2001

Materials and methods

Principles of method if other than guideline:
The present primary skin Irritation study was conducted with 10 human volunteers (5 men, 5 women) to determine whether the test compound was irritating to human skin or not. The test was conducted according to Shelanski & Shelanski (Occluded Patch Test, 1953).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-oxydiethanol
EC Number:
203-872-2
EC Name:
2,2'-oxydiethanol
Cas Number:
111-46-6
Molecular formula:
C4H10O3
IUPAC Name:
2-(2-hydroxyethoxy)ethan-1-ol
Details on test material:
purity: >96%; no further details provided.

Test animals

Species:
human

Test system

Type of coverage:
occlusive
Preparation of test site:
other: none
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
Three areas of 3 cm x 3 cm each, were selected on the skin of the left arm of each individual. 10 mg of the test substance was applied to each area as a finely ground powder. The powder was covered with a lintine disc and secured to the arm by sealing around the edges with Blenderm tape.
Duration of treatment / exposure:
After 2 hours, the cover of one contact area was removed from each subject, the powder was lightly brushed away, and the site examined for skin reactions.
After 4 hours, the second disk was removed and the skin examined.
After 6 hours, the third disk was removed and the skin examined.
All treatment sites were examined immediately after disk removal, and then again at 1, 4 and 24 hour intervals.
Number of animals:
Ten human volunteers (5 men, 5 women)

Results and discussion

In vivo

Results
Irritation parameter:
other: each application site was examined for skin reaction
Basis:
other: each volunteer
Reversibility:
fully reversible within: 24 h
Remarks on result:
other: One male subject exhibited slight erythema at 4 hours and marked erythema at 6 hours. One female subject exhibited slight erythema at 6 hours, and one female subject had marked erythema at 6 hours. All reactions disappeared in less than 24 hours.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Conclusions:
The test compound was able to elicite very mild primary irritation effect on human skin which however was fully reversible within less than 24 hours.