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EC number: 205-500-4 | CAS number: 141-78-6
Decreases in MA were observed for males and female rats exposed to 300 or 6000 ppm ethyl acetate when measured approximately 1 hour post-exposure. The decrease in motor activity persisted for the 6000 ppm exposure groups when measured on the morning of the day following exposure. There were no other changes in MA noted for any groups during the post-exposure assessment period. FOB endpoints indicative of sedation were observed solely at the initial post-exposure measurement period in animals exposed to 3000 or 6000 ppm. The NOEL for systemic toxicity was less than 600 ppm based upon the transient decrease in body weights noted on the first day after exposure. The NOEL for neurotoxicity was 600 ppm. The LOEL for neurotoxicity (sedation) was 3000 ppm.
In a guideline and GLP study inhalation study, carried out using a 6 -hr whole body exposure, the LCLo was established to be >6,000 ppm (22.5 mg/L), the maximum dose tested. The acute NOEC for neurotoxicity was 600 ppm (2.25 mg/L) based on sedation at higher concentrations.
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