Registration Dossier
Registration Dossier
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EC number: 205-500-4 | CAS number: 141-78-6
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1968
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Included for completion purposes only. Study not fully reviewed as waiver available for this end point.
Data source
Reference
- Reference Type:
- publication
- Title:
- "Horny layer injury by solvents".
- Author:
- Malten KE; Spruit D; Boemaars HG; Keizer M.J.
- Year:
- 1 968
- Bibliographic source:
- Berufsdermatosen 16, 135 - 147
Materials and methods
- Type of study / information:
- Type of experience: Human
- Endpoint addressed:
- dermal absorption
- skin irritation / corrosion
- Principles of method if other than guideline:
- Assessment of damage caused to skin barrier properties by measuring transdermal water loss after skin exposure to solvent.
Test material
- Reference substance name:
- Ethyl acetate
- EC Number:
- 205-500-4
- EC Name:
- Ethyl acetate
- Cas Number:
- 141-78-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- ethyl acetate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
A study reported that application of ethyl acetate to (probably) three volunteers for 1 h/d for 6 days resulted in damage to the outer skin layer (stratum corneum), as measured by an increase in the rate of water vapour loss from the skin.
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