Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 202-496-6 | CAS number: 96-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
The hydrolysis of MEKO was dependent on pH, but much less dependent on temperature. At pH 4, MEKO was hydrolytically unstable, regardless of the temperature (t1/2 < 0.3 min), at pH 7, the hydrolysis reaction is much slower; 14% hydrolysis at 20 °C was obtained after 4 days and 44% hydrolysis was obtained at 50 °C after 7 days and at pH 9, no measurable hydrolysis under any of the test conditions was observed. Since from the above results no DT50 could be determined at pH7 in the assessment it is assumed that MEKO is not hydrolysable.
MEKO does not meet the requirements for ready biodegradation in an OECD 301 C guideline study, but is considered inherently biodegradable when evaluated in an OECD 302 B guideline study. As the specific criteria for inherent biodegradation are not passed, in the assessment MEKO is characterised as “Inherently biodegradable, not fulfilling specific criteria”.
The calculated log Koc of 0.55 using KOCWIN™ v2.00 indicates that MEKO is not likely to adsorb to soil or sediment.
Measured BCF values ranging from 0.5 to 5.8 indicate that MEKO is not expected to bioaccumulate.
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