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Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Endpoint:
fish short-term toxicity test on embryo and sac-fry stages
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well documented and well performed according to scientific standards

Data source

Reference
Reference Type:
publication
Title:
Acute and chronic toxicities of arsenic(III) to fathead minnows, flagfish, daphnids and an amphipod
Author:
Lima AR, Curtis C, Hammermeister DE, Markee TP, Northcott CE, Brooke LT
Year:
1984
Bibliographic source:
Archieves of Environmental Contamination and Toxicology 13, 595-601

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Long-term toxicity on growth of fish
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
other: various species
Details on test organisms:
Jordanella floridae
Pimephales promelas

Study design

Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
38 d
Post exposure observation period:
Jordanella floridae: ca. 7 d hatching time + 31 d
Pimephales promelas: ca. 6 d hatching time + 29 d

Test conditions

Hardness:
46.3-49.9 mg/L CaCO3
Test temperature:
23-25.8 °C
pH:
7.2-8.1
Nominal and measured concentrations:
Test concentration were analytically confirmed.

Results and discussion

Effect concentrationsopen allclose all
Duration:
35 d
Dose descriptor:
NOEC
Effect conc.:
2.13 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
dissolved
Basis for effect:
other: growth ,length and wet weight
Remarks on result:
other: Pimephales promelas
Duration:
35 d
Dose descriptor:
LOEC
Effect conc.:
4.3 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
dissolved
Basis for effect:
other: growth, length and wet weight
Remarks on result:
other: Pimephales promelas
Duration:
38 d
Dose descriptor:
NOEC
Effect conc.:
2.13 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
dissolved
Basis for effect:
other: growth, length and wet weight
Remarks on result:
other: Jordanella floridae
Duration:
38 d
Dose descriptor:
LOEC
Effect conc.:
4.12 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
dissolved
Basis for effect:
other: growth, length and wet weight
Remarks on result:
other: Jordanella floridae

Applicant's summary and conclusion

Conclusions:
The lowest reliable long-term NOEC value reported for freshwater fish is 2.13 mg/L for the growth of Pimephales promelas and Jordanella floridae, and this NOEC value is considered for the Chemicals Safety Assessment.