Registration Dossier
Registration Dossier
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EC number: 202-429-0 | CAS number: 95-53-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.013 mg/L
Additional information
The lowest chronic test result obtained for Daphnia magna was in a GLP-test according to the OECD TG 202. A NOEC of 0.0126 mg/l and a LOEC of 0.04 mg/l were determined for the endpoint reproduction in a GLP-test according to the OECD TG 202 (CERI, 1996). The results are based on nominal concentrations of test material, since analytical monitoring with HPLC was performed and the test concentrations were confirmed. The test was conducted under flow-through conditions.
Chronic toxicity towards Daphnia magna was investigated also in a test according to the Dutch Standardization Organization Method NEN 6502. A 21 d-EC50 of 2.2 mg/l was obtained for the endpoint immobilisation. Endpoints population growth and length were also observed. For the endpoint population growth, a LRCT value (lowest rejected concentration tested) of 0.1 mg/l was reported. This value is similar to a LOEC (lowest observed effect concentration). The test was conducted with 17 anilines. The test concentrations were represented by the means of one aniline (2,4-dichloroaniline): 0.01, 0.032, 0.1, 0.32, 1.0, 3.2, 10.0 mg/l. In the summary table only the LOECs of the test substances were given. For o-toluidine (LOEC 0.1 mg/l) a NOEC of 0.032 mg/l can be derived in respect to the tested concentrations.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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