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EC number: 202-429-0 | CAS number: 95-53-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Concerning the aquatic effects short term toxicity, tests for each trophic level are available and concerning long term toxicity, two tests with species representing two trophic level are available.
The most sensitive species was Daphnia magna followed by algae.
It is not clear whether analytical monitoring was performed in all available test, but studies with analytical monitoring indicated that the substance was stable in water, constant exposure concentrations over the test duration can be assumed.
For various fish species short term toxicity tests are available, with LC50 (96h) values ranging from 82.5 to 151 mg/l.
The most sensitive value on toxicity to fish was determined in a test conducted with a method which was in most parts equivalent to the OECD guideline 204 (Fish, prolonged toxicity test). A 14day-LC50 of 81.3 mg/L was determined on Poecilia reticulata.
Concerning acute toxicity of o-toluidine to the invertebrate Daphnia magna, Maas-Dieperveen reported a 48 hours EC50 value of 0.52 mg/L which is the most sensitive value. The test was performed according to the Dutch Standardization Organization Method NEN 6501 without analytical monitoring.
Concerning the algal toxicity, tests on three different species are available. The lowest available EC50 based on growth rate, was 110.5 mg/l after 72 hours, in a test carried out according to the OECD TG 201 towards Selenastrum capricornutum. A NOEC of 2.91mg/l was determined for the endpoint growth rate.
The lowest chronic test result obtained for Daphnia magna was in a GLP-test according to the OECD TG 202. An NOEC of 0.0126 mg/l and a LOEC of 0.04 mg/l were determined for the endpoint reproduction in a GLP-test according to the OECD TG 202 (CERI, 1996).
Toxicity to Microorganisms was investigated towards Tetrahymena pyriformis.
The toxicity of o-toluidine to Tetrahymena pyriformis was tested in a 40 hours test using the population growth impairment as endpoint. The test was performed according to the method described by Schultz (1997). An EC50 of ca. 155 mg/l was observed (Schultz, 1999).
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