Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-429-0 | CAS number: 95-53-4
Endpoint summary
Administrative data
Description of key information
Additional information
Concerning the aquatic effects short term toxicity, tests for each trophic level are available and concerning long term toxicity, two tests with species representing two trophic level are available.
The most sensitive species was Daphnia magna followed by algae.
It is not clear whether analytical monitoring was performed in all available test, but studies with analytical monitoring indicated that the substance was stable in water, constant exposure concentrations over the test duration can be assumed.
For various fish species short term toxicity tests are available, with LC50 (96h) values ranging from 82.5 to 151 mg/l.
The most sensitive value on toxicity to fish was determined in a test conducted with a method which was in most parts equivalent to the OECD guideline 204 (Fish, prolonged toxicity test). A 14day-LC50 of 81.3 mg/L was determined on Poecilia reticulata.
Concerning acute toxicity of o-toluidine to the invertebrate Daphnia magna, Maas-Dieperveen reported a 48 hours EC50 value of 0.52 mg/L which is the most sensitive value. The test was performed according to the Dutch Standardization Organization Method NEN 6501 without analytical monitoring.
Concerning the algal toxicity, tests on three different species are available. The lowest available EC50 based on growth rate, was 110.5 mg/l after 72 hours, in a test carried out according to the OECD TG 201 towards Selenastrum capricornutum. A NOEC of 2.91mg/l was determined for the endpoint growth rate.
The lowest chronic test result obtained for Daphnia magna was in a GLP-test according to the OECD TG 202. An NOEC of 0.0126 mg/l and a LOEC of 0.04 mg/l were determined for the endpoint reproduction in a GLP-test according to the OECD TG 202 (CERI, 1996).
Toxicity to Microorganisms was investigated towards Tetrahymena pyriformis.
The toxicity of o-toluidine to Tetrahymena pyriformis was tested in a 40 hours test using the population growth impairment as endpoint. The test was performed according to the method described by Schultz (1997). An EC50 of ca. 155 mg/l was observed (Schultz, 1999).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
