o-toluidine

Guidance on Safe Use

First-aid measures

Inhalation: Get medical attention immediately. If inhaled, remove to fresh air. If it is suspected that fumes are still present, the rescuer should wear

an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth

resuscitation. Keep person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial

respiration or oxygen by trained personnel. In case of inhalation of gas, symptoms may be delayed. Medical surveillance for at least 48

hours.

Ingestion: Get medical attention immediately. Wash out mouth with water.

Keep person warm and at rest. Ensure that the patient drinks

water, possibly with the addition of activated charcoal. Do not

induce vomiting unless directed to do so by medical personnel.

Never give anything by mouth to an unconscious person. If

unconscious, place in recovery position and get medical attention

immediately. Maintain an open airway.

Notes to medical doctor

Therapeutic measures: Elementary aid, decontamination,

symptomatic treatment and depending on the formation of

methaemoglobin: intravenous administration of toluidine blue or

other redox dyes according to dosage specifications plus ascorbic

acid.

Skin contact: Get medical attention immediately. Wash skin immediately with

plenty of water and soap. Subsequent cleansing with

polyethyleneglycol 400, then again with water and soap. Use no

solvent. Continue to rinse for at least 10 minutes. In case of

blueness of lips, skin or nails (cyanosis) let the person breathe

oxygen. No consumption of alcohol after product contact. No

physical exertion. Remove contaminated clothing and shoes. Wash

clothing before reuse. Clean shoes thoroughly before reuse.

Carefully clean hair, under the nails, and other hidden areas.

Eye contact: Immediately flush eyes with running water for at least 15 minutes,

keeping eyelids open. Get medical attention immediately.

Fire-fighting measures

Suitable extinguishing media: Use dry chemical, CO2, water spray (fog) or foam.

Unsuitable extinguishing media: Do not use water jet.

Special exposure hazards: Combustible liquid. In a fire or if heated, a pressure increase will occur and the container may burst, with the risk of a subsequent explosion.

Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving

any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep

fire-exposed containers cool. This material is very toxic to aquatic organisms. Fire water contaminated with this material must be

contained and prevented from being discharged to any waterway, sewer or drain.

Hazardous combustion products: Decomposition products may include the  following materials: carbon oxides, nitrogen oxides.

Special protective equipment for fire-fighters: Fire-fighters should wear appropriate protective equipment and selfcontained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Accidental release measures

Personal precautions: Avoid exposure - obtain special instructions before use. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material.

Shut off all ignition sources. No flares, smoking or flames in hazard area. Avoid breathing vapour or mist. Provide adequate ventilation.

Put on appropriate personal protective equipment

Environmental precautions: Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Very toxic to aquatic organisms.

Large spill: Stop leak if without risk. Move containers from spill area. Prevent entry into sewers, water courses, basements or confined areas.

Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations.

Use spark-proof tools and explosion-proof equipment. Dispose of via a licensed waste disposal contractor. Contaminated absorbent material may pose the same hazard as the spilt product.

Small spill: Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble or absorb with an inert dry

material and place in an appropriate waste disposal container. Use spark-proof tools and explosion-proof equipment. Dispose of via a

licensed waste disposal contractor.

Handling and storage

This substance is handled under Strictly Controlled Conditions in  accordance with REACH regulation Article 17(3) for on-site isolated  intermediates and, in case the substance is transported to other sites for  further processing, the substance should be handled at these sites under  the Strictly Controlled Conditions as specified in REACH regulation  Article 18(4). Site documentation to support safe handling arrangements  including the selection of engineering, administrative and personal  protective equipment controls in accordance with risk-based management  systems is available at each Manufacturing site.  

Written confirmation of application of Strictly Controlled Conditions has  been received from affected Distributor and Downstream  Manufacturer/User of the Registrant's intermediate.  

Handling: Avoid exposure - obtain special instructions before use. Put on appropriate personal protective equipment. Eating,

drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash

hands and face before eating, drinking and smoking. Do not get in eyes or on skin or clothing. Do not breathe vapour or mist. Do not

ingest. Avoid release to the environment. Use only with adequate ventilation. Wear appropriate respirator when ventilation is

inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved

alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame

or any other ignition source. Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Use nonsparking

tools. Take precautionary measures against electrostatic discharges. To avoid fire or explosion, dissipate static electricity

during transfer by earthing and bonding containers and equipment before transferring material. Empty containers retain product

residue and can be hazardous.

Storage: Store in accordance with local regulations. Store in a segregated and approved area. Store in original container protected from direct

sunlight in a dry, cool and well-ventilated area, away from incompatible materials and food and drink.

Eliminate all ignition sources. Separate from oxidizing materials.

Keep container tightly closed and sealed until ready for use.

Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers.

Use appropriate containment to avoid environmental contamination.

Packaging materials: Recommended: Use original container.

Packaging materials: Remarks: Make sure all pipelines, tanks and equipment are leakproof. Ensure effective ventilation. Vent waste air only via suitable separators or scrubbers.

The product is registered with strictly controlled conditions as defined in Article 18(4) of regulation (EC) no. 1907/2006 (REACH Regulation) and must therefore be handled as such. Refer to the industry guidance prepared by Concawe/Cefic/EFCG for advice on the confirmation of strictly controlled conditions.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN1708

Shipping information

Proper shipping name and description:

TOLUIDINES, LIQUID

Chemical name:

o-toluidine

Language:

English

Labels:

Toxic substances Symbol (skull and crossbones): black;
Background: white; Figure '6' in bottom corner

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN1708

Shipping

Labels:

Toxic substances Symbol (skull and crossbones): black;
Background: white; Figure '6' in bottom corner

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN1708

Shipping information

Proper shipping name and description:

TOLUIDINES, LIQUID

Chemical name:

o-toluidine

Labels:

Toxic substances Symbol (skull and crossbones): black;
Background: white; Figure '6' in bottom corner

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN1708

Shipping information

Proper shipping name and description:

TOLUIDINES, LIQUID

Chemical name:

o-toluidine

Labels:

Toxic substances Symbol (skull and crossbones): black;
Background: white; Figure '6' in bottom corner

Special provisions / remarks

Remarks:

Passenger aircraft: 609: 5 L
Cargo aircraft: 611: 60 L

Additional transport information

Additional information

Special provisions / remarks / other:

Toxic.
Combustible.
Flash point (Closed cup): 83°C (DIN 51758)
Keep separated from foodstuffs.

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in  accordance with REACH regulation Article 17(3) for on-site isolated  intermediates and, in case the substance is transported to other sites for  further processing, the substance should be handled at these sites under  the Strictly Controlled Conditions as specified in REACH regulation  Article 18(4). Site documentation to support safe handling arrangements  including the selection of engineering, administrative and personal  protective equipment controls in accordance with risk-based management  systems is available at each Manufacturing site.  

Occupational exposure limits: Not available.

o-toluidine:

No workplace limit value(OEL) fixed. Additional protective measures must be complied with, in particular:

- Measurements for the early detection of increased exposure as a result of an unforeseen incident;

- Cordoning off of the hazardous areas and display of warning and hazard signs, including a sign

saying "Smoking prohibited", in areas where exposure is possible;

-       Extracted air must not be returned to the system without being treated first.

Recommended monitoring procedures: If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to European Standard EN 689 for methods for the assessment of exposure by inhalation to chemical agents and national guidance documents for methods for the determination of hazardous substances.

Risk management measures - Occupational exposure controls

Technical measures: Use only with adequate ventilation. Use process enclosures, local

exhaust ventilation or other engineering controls to keep worker

exposure to airborne contaminants below any recommended or

statutory limits. The engineering controls also need to keep gas,

vapour or dust concentrations below any lower explosive limits. Use

explosion-proof ventilation equipment. The substance shall be rigorously contained by technical means during its whole lifecycle including manufacture, purification,

cleaning and maintenance of equipment, sampling, analysis,

loading and unloading of equipment or vessels, waste disposal or

purification and storage. Procedural and control technologies shall

be used that minimise emission and any resulting exposure. In

cases of accident and where waste is generated, procedural and/or

control technologies shall be used to minimise emissions and the

resulting exposure during purification or cleaning and maintenance

procedures.

Organisational measures: Only properly trained and authorised personnel shall handle the substance. In the case of cleaning and maintenance works, special

procedures such as purging and washing shall be applied before

the system is opened and entered.

Risk management measures - Personal protection measures

Respiratory protection: If exposure cannot be ruled out, e.g. during product transfer,

sampling or maintenance, a well-fitting respiratory mask conforming

to standards or well-fitting respiratory device conforming to

standards must be worn. Respirator selection must be based on

known or anticipated exposure levels, the hazards of the product

and the safe working limits of the selected respirator.

Recommended: Full mask with type ABEK filter or self-contained

breathing apparatus (SCBA)

Hand protection: Chemical-resistant, impervious gloves complying with an approved

standard should be worn at all times when handling chemical

products if product contact cannot be excluded. After contamination

with product change the gloves immediately and dispose of them

according to relevant national and local regulations

<1 hours (breakthrough time): Butyl rubber - IIR, Nitrile rubber -

NBR, Fluorinated rubber - FKM, Polychloroprene - CR or Polyvinyl

chloride - PVC

Eye protection: Safety eyewear complying with an approved standard should be

used to avoid exposure to liquid splashes, mists, gases or dusts.

Recommended: Tightly fitting safety goggles.

Skin protection: Wear protective clothing. Personal protective equipment for the

body should be selected based on the task being performed and the

risks involved and should be approved by a specialist before

handling this product.

Hygiene measures: Wash hands, forearms and face thoroughly after handling chemical

products, before eating, smoking and using the lavatory and at the

end of the working period. Appropriate techniques should be used

to remove potentially contaminated clothing. Wash contaminated

clothing before reusing. Ensure that eyewash stations and safety

showers are close to the workstation location.

Risk management measures - Environmental exposure controls

Technical measures: Emissions from ventilation or work process equipment should be

checked to ensure they comply with the requirements of

environmental protection legislation. In some cases, special waste

water treatment, fume scrubbers, filters or engineering

modifications to the process equipment will be necessary to reduce

emissions to acceptable levels.

Stability and reactivity

Stability : The product is stable.

Possibility of hazardous reactions: Under normal conditions of storage and use, hazardous reactions will not occur.

Conditions to avoid: In the case of dusty organic products the possibility of a dust

explosion should always be considered.

Hazardous decomposition products: Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Disposal considerations

Methods of disposal: Examine possibilities for re-utilisation. Product residues and

uncleaned empty containers should be packaged, sealed, labelled,

and disposed of or recycled according to relevant national and local

regulations. Where large quantities are concerned, consult the

supplier. When uncleaned empty containers are passed on, the

recipient must be warned of any possible hazard that may be

caused by residues. For disposal within the EC, the appropriate

code according to the European Waste List (EWL) should be used.

It is among the tasks of the polluter to assign the waste to waste

codes specific to industrial sectors and processes according to the

European Waste List (EWL).

Hazardous waste: The classification of the product may meet the criteria for a

hazardous waste.