Registration Dossier

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: effects on fertility on parent animals
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference not translated, and only short abstract available

Data source

Reference
Title:
No information
Author:
Malysheva MV, Saitzeva EP, Ivanov YuV (1983) Effects after dermal application with o-toluidine in rats. Gig Tr Prof Zabol 9: 47-49

Materials and methods

Principles of method if other than guideline:
Method: other: see TC
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
o-toluidine
EC Number:
202-429-0
EC Name:
o-toluidine
Cas Number:
95-53-4
Molecular formula:
C7H9N
IUPAC Name:
o-toluidine
Details on test material:
IUCLID4 Test substance: other TS: o-toluidine, no data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
dermal
Duration of treatment / exposure:
Exposure period: 4 month
Frequency of treatment:
4 h/day
Doses / concentrations
Remarks:
Doses / Concentrations:
8, 80 mg/kg bw
Basis:

Control animals:
yes

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Effects on treated animals (P):
---increased cell numbers of the spermatogenetic tissues
---no differences on spermatogenesis during the recovery period
---increased number of corpus luteum in ovaries
---no differences on fertility and number of implants observed

for effects on progeny (F1): see chapter 5.8.2

Applicant's summary and conclusion