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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
No information
Author:
Katz AE
Year:
1946
Bibliographic source:
The Spice Mill, 69, 46-47, 50-51
Reference Type:
secondary source
Title:
No information
Author:
Katz AE
Year:
2008
Bibliographic source:
RIFM database

Materials and methods

Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Ethical approval:
not specified
Details on exposure:
A 24 hour closed patch test was conducted on male and female volunteers.
Test material was applied undiluted to an area on the inner arm of the subjects measuring 1 cm in diameter.
Crystalline substances were applied in the same manner except as saturated alcoholic solutions. Immediately following application, the area was covered with an adhesive bandage for 24 hours. Reactions were read daily for 5 days.
Applications which produced visible inflammation, irritation, formation of a popular rash, or any abnormal condition of the area, were considered positive reactions. All positive reactions were confirmed by repetition of the test on the same subject after complete disappearance of positive systems. Results listed are number of positive reactions observed in the number of tests conducted

Results and discussion

Results:
No effects, no positive reactions were observed in 20 tests

Applicant's summary and conclusion