Registration Dossier
Registration Dossier
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EC number: 203-375-0 | CAS number: 106-22-9
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Katz AE
- Year:
- 1 946
- Bibliographic source:
- The Spice Mill, 69, 46-47, 50-51
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Katz AE
- Year:
- 2 008
- Bibliographic source:
- RIFM database
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Citronellol
- EC Number:
- 203-375-0
- EC Name:
- Citronellol
- Cas Number:
- 106-22-9
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-ol
Constituent 1
Method
- Ethical approval:
- not specified
- Details on exposure:
- A 24 hour closed patch test was conducted on male and female volunteers.
Test material was applied undiluted to an area on the inner arm of the subjects measuring 1 cm in diameter.
Crystalline substances were applied in the same manner except as saturated alcoholic solutions. Immediately following application, the area was covered with an adhesive bandage for 24 hours. Reactions were read daily for 5 days.
Applications which produced visible inflammation, irritation, formation of a popular rash, or any abnormal condition of the area, were considered positive reactions. All positive reactions were confirmed by repetition of the test on the same subject after complete disappearance of positive systems. Results listed are number of positive reactions observed in the number of tests conducted
Results and discussion
- Results:
- No effects, no positive reactions were observed in 20 tests
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
