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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Metabolism of Geraniol and Linalool in the Rat and effects on liver and Lung Microsomal Enzymes.
Author:
Chadha A, Madyastha M
Year:
1984
Bibliographic source:
Xenobiotica 14: 365-374
Reference Type:
secondary source
Title:
No information
Author:
Chadha A, Madyastha M
Year:
2008
Bibliographic source:
RIFM database

Materials and methods

Objective of study:
metabolism
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Geraniol
- Analytical purity: >99.5% pure,

Test animals

Species:
rat
Strain:
other: IISc strain
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 160 - 200 g
- Housing: after dosing individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
VEHICLE
- Concentration: 1%
Duration and frequency of treatment / exposure:
6 days
Doses / concentrations
Remarks:
Doses / Concentrations:
600 mg/kg bw/d
Control animals:
yes, concurrent vehicle
Details on dosing and sampling:
PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled . liver, lung
- Time and frequency of sampling:24 h after 1, 3 or 6 doses.

Results and discussion

Any other information on results incl. tables

Results:

- Significant increase in liver cytochrome P-450 after 3 days.

- steady increase in liver geraniol hydroxylase activity (36% at 6 days).

- No change in cytochrome b5, NADPH- or NADH-cytochrome c reductases.

- No effect on any parameter using lung microsome.

Applicant's summary and conclusion