Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973
Reference Type:
secondary source
Title:
Fragrance Raw Materials
Author:
Opdyke DLJ
Year:
1975
Bibliographic source:
Food Cosmet. Toxicol. 13, 757 - 758
Reference Type:
secondary source
Title:
No information
Author:
Moreno OM
Year:
2001
Bibliographic source:
RTECS: Update 199701, (2000/01)
Reference Type:
secondary source
Title:
Unnamed
Year:
2006
Reference Type:
secondary source
Title:
ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS, ALDEHYDES, ACIDS, AND RELATED ESTERS
Author:
Pronk IMEJ
Year:
2007
Bibliographic source:
First draft; WHO Info

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: other: acute oral toxicity
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
2025, 2560, 3200, 4000, 5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 450 mg/kg bw
95% CL:
3 210 - 3 690
Mortality:
5000 mg/kg bw: 8/10
4000 mg/kg bw: 6/10
3200 mg/kg bw: 7/10
2560 mg/kg bw: 0/10
2050 mg/kg bw: 1/10

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU