Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973
Reference Type:
secondary source
Title:
Fragrance Raw Materials
Author:
Opdyke DLJ
Year:
1975
Bibliographic source:
Food Cosmet. Toxicol. 13, 757 - 758
Reference Type:
secondary source
Title:
RTECS: Update 199701, (2000/01)
Author:
Moreno OM
Year:
2001
Bibliographic source:
RTECS: Update 199701
Reference Type:
secondary source
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
acute dermal toxicity
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
1250, 2500, 5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 650 mg/kg bw
95% CL:
1 780 - 3 520
Mortality:
5000 mg/kg bw: 5/5
2500 mg/kg bw: 2/5
1250 mg/kg bw: 0/5
Clinical signs:
5000 mg/kg bw: ataxia and pupillary dilation
2500 mg/kg bw: ataxia in 4 animals
1250 mg/kg bw: 2 animals were weak and unable to stand

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU