Registration Dossier
Registration Dossier
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EC number: 212-081-1 | CAS number: 760-67-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound valeryl chloride: No data.
Hydrolysis product 2-ethylhexanoic acid: Acutely harmful to aquatic invertebrates.
Hydrolysis product HCl: Acutely very toxic for aquatic invertebrates (pH dependent).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- Hydrolysis product 2-ethylhexanoic acid (CAS 149-57-5)
- Effect concentration:
- 48.7 mg/L
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- Hydrolysis product hydrochloric acid (HCl; CAS 7647 -01 -0)
- Effect concentration:
- 0.492 mg/L
Additional information
Parent compound 2 -ethylhexanoyl chloride (CAS 760-67-8):
No data are available for 2 -ethylhexanoyl chloride. The substance rapidly decomposes in water and forms2-ethylhexanoic acid (CAS 149-57-5) and hydrochloric acid (HCl, CAS 7647 -01 -0). Therefore, the short-term toxicity to aquatic invertebrates is assessed on the basis of data on 2-ethylhexanoic acid.
Hydrolysis product 2-ethylhexanoic acid (CAS 149-57-5):
A study is available to assess the short-term toxicity of 2-ethylhexanoic acidtowards aquatic invertebrates. The 48 -h LC50 determined with the waterflea (Daphnia magna) was 85.4 mg/L (nominal; BASF AG, 1988). No analytical measurements were performed during the study. However, the information on the stability of the test item in the test solutions is available in the acute toxicity fish test (see IUCLID Ch. 6.1.1). The test item was not stable during the test, based on the measured concentrations during the study. Therefore, the derived EC50 value were corrected with regard to the available geometric mean recovery values presented in the acute fish test. For more details see attached datafile in the corresponded endpoint study record under attached background materials. Overall, the corrected EC50 value of 48.7 mg/L was used as a key value.
In conclusion,2-ethylhexanoic acidis considered to be acutely harmful to aquatic invertebrates.
Hydrolysis product hydrochloric acid (HCl; CAS 7647 -01 -0):
The hydrolysis product hydrochloric acid (HCl) was tested in a semi-static acute toxicity test according to OECD 202 with Daphnia magna. The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3; OECD SIDS, 2002).
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