Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-081-1 | CAS number: 760-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- publication
- Title:
- Five Toxicity Screening Studies with 2-Ethylhexanoyl chloride
- Author:
- PPG Ind. Inc., USA
- Year:
- 1 987
- Bibliographic source:
- TSCATS, OTS 0513463, Doc. I.D. 89-878000001
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for SIAM 27 - Acid Chlorides (AC) Category
- Author:
- OECD SIDS
- Year:
- 2 008
- Bibliographic source:
- OECD SIDS
Materials and methods
- Principles of method if other than guideline:
- Acute inhalation toxicity study with rats (1 h).
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexanoyl chloride
- EC Number:
- 212-081-1
- EC Name:
- 2-ethylhexanoyl chloride
- Cas Number:
- 760-67-8
- Molecular formula:
- C8H15ClO
- IUPAC Name:
- 2-ethylhexanoyl chloride
- Details on test material:
- Purity of test material was not analytically confirmed. It was used as received from PPG Industries. Purity of that material is listed as > 98% on the MSDS.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals (15 males and 20 females) were acclimated for at least one week before use. The males and females weighed 265-315 g and 198-246 g when tested, respectively. Food and water were available ad libitum (except during exposure). Animals were randomized to groups of 5 animals/sex.
exposure
Administration / exposure
- Route of administration:
- other: The test material was generated as an aerosol. However, the material the animals were exposed to may have been vapor indicated by the volatility of the material.
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The aerosol was generated by pumping the test material through a pressure operated spray nozzle. The aerosol was diluted with dried, filtered air and drawn into the exposure chamber. Air flow into the chamber was maintained through the use of a calibrated critical orifice. Air flow was recorded at 30 min intervals during the exposure period. Air flow was sufficient to ensure adequate oxygenation of the exposure atmosphere. Temperature and humidity were recorded at 30 min intervals from a wet bulb/dry bulb hygrometer located in the exposure chamber.
The concentration of test material in atmosphere samples collected twice for each exposure (at 30 and 60 minutes) was determined analytically using a gas chromatograph. The nominal concentration was determined by dividing the loss in weight of the test material after exposure by the total volume of air that passed through the chamber. Due to the volatility of the test material, gravimetric and particle size determinations could not be performed. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 1 h
- Concentrations:
- 0.834, 1.16, 1.23 (here only females were tested) and 1.47 mg/L (analytical; corresponding to 1.06, 1.91, 2.05 and 2.61 mg/L nominal)
- Details on study design:
- Animals were observed frequently on the day of exposure (4 animals per group) and at least once daily thereafter (all animals) for 14 days for signs of toxicity. Individual body weights were recorded just prior to exposure and on days 7 and 14 (or as soon as possible after death). Gross necropsies were performed on all animals upon euthanization on day 14 or as soon as possible after death.
- Statistics:
- The LD50 values were calculated by the method of Litchfield and Wilcoxon (J Pharm Ther 96:99-115, 1949).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1.26 mg/L air
- 95% CL:
- 1.18 - 1.34
- Exp. duration:
- 1 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1.13 mg/L air (analytical)
- 95% CL:
- 1.01 - 1.27
- Exp. duration:
- 1 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 1.34 mg/L air (analytical)
- Exp. duration:
- 1 h
- Mortality:
- The number of deaths (and time of death) was as follows:
0.834 mg/l: 0/5 males, 0/5 females
1.116 mg/l: 3/5 males (2 hr to Day 1), 0/5 females
1.23 mg/l: 5/5 females (from 2 hr to Day 1)
1.47 mg l: 5/5 males and 5/5 females (from 2 hr to Day 1) - Clinical signs:
- other: Signs observed over the course of the study were activity decrease, constricted pupils, dilated pupils, emaciation, epistaxis, gasping, lacrimation, nasal discharge, piloerection, polyuria, ptosis, respiratory gurgle, and/or salivation.
- Body weight:
- Thirteen (3 animals exposed to 0.834 mg/l, 6 animals exposed to 1.16 mg/l, and 4 animals exposed to 1.23 mg/l) of the 22 animals that survived for 14 days gained weight.
- Gross pathology:
- Gross necropsy findings in animals that died before and at study termination included emaciation, lacrimation, nasal discharge, polyuria, salivation,
discoloration of lungs and contents of the GI tract, lungs edematous, and/or GI tract distended with gas.
Discoloration of the lungs, lung distension and edema were observed at necropsy in 9/10 surviving animals exposed to 0.834 mg/l. No significant findings were noted in one female exposed to 0.834 mg/l and all survivors exposed to 1.16 or 1.23 mg/l. - Other findings:
- The relative humidities and temperatures of all five chambers ranged from 60-77% and 21-23°C, respectively. The flow rates of all chambers were
maintained at 138.8 lpm (with the exception of the chamber containing 1.23 mg/l, which was 99.8 lpm).
Any other information on results incl. tables
The test
material was generated as an aerosol. However,
the material the animals were exposed to may have been vapor indicated
by the volatility of the material. Particle
sizing was not attempted.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
