Registration Dossier

Administrative data

Description of key information

2-Ethylhexanoyl chloride is corrosive to the skin, and therefore also to the eye according to GHS directive, Annex I,

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information


In a guideline study (OECD TG 404), undiluted 2 -ethylhexanoyl chloride (0.5 mL) was applied to the clipped intact skin of New Zealand White rabbits (3/sex) under semi-occlusive conditions for 4 hours (Stillmeadow, 1986). The animals were scored for erythema and eschar formation, edema formation and any other dermal effects or irritation at 1, 24, 48, and 72 hours and 4, 7, 10, 14, 17 and 21 days after removal of the patch. The maximum irritation score of 6.8/8.0 was obtained at the Day 7 observation time. Erythema and oedema were present at each observation time through Day 21, indicating the substance is corrosive to skin.


0.1 mL 2 -ethylhexanoyl chloride was placed into the conjunctival sac of the right eye of each of 9 rabbits (strain not specified;Stillmeadow 1986). The lids were held together for one second. Three of the nine treated eyes were each washed with water for 1 minute, 30 seconds after treatment. The untreated left eye served as a control. A maximum average irritation score of 21.8 was obtained for nonwashed eyes 1 hour after treatment. The score for washed eyes at this time was 13.3. Positive staining (with 0.2% fluorescein sodium ophthalmic solution) occurred in four unwashed eyes, which resolved by 48 hours. Positive staining did not occur in any of the washed eyes. EhCl was rated mildly irritating.

According to GHS directive, Annex I, due to corrosivity to the skin, EhCl is also corrosive to the eye.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

According to the results of the skin irritation study 2 -ethylhexanoyl chloride is classified as corrosive according to Annex I of Directive 1272/2008 (EU-GHS: Skin Corr 1B, H314 and therefore also Eye Damage 1) and according to Annex VI of Directive 67/548/EWG (DSD: R34, Corrosive).