Registration Dossier
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EC number: 212-081-1 | CAS number: 760-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed and documented in a robust manner (adopted from OECD SIDS; however, results are not reported in sufficient detail for classification)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 986
- Report Date:
- 1986
- Reference Type:
- publication
- Title:
- No information
- Author:
- PPG Ind. Inc.
- Year:
- 1 987
- Bibliographic source:
- TSCATS, OTS 0513463, Doc. I.D. 89-878000001
Materials and methods
Test guideline
- Qualifier:
- according to
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Purity of test material was not analytically confirmed. It was used as received from PPG Industries. Purity of that material is listed as > 98% on the MSDS.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals and environmental conditions:
- Three female and three male New Zealand White rabbits were used.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Undiluted test material (0.5 ml) was placed on clipped skin under a gauze patch. Each patch was secured with a strip of non-irritating adhesive tape and the entire trunk of the animal was wrapped with a semi-permeable dressing. The dressings were removed 4 hours later and the skin was gently wiped with a moist cloth to remove as much residual material as possible.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 21 d
- Number of animals:
- 6
- Details on study design:
- The animals were scored for erythema and eschar formation, edema formation and any other dermal effects or irritation at 1, 24, 48, and 72 hours and 4, 7, 10, 14, 17 and 21 days after removal of the dressings. The maximum score for each endpoint was 4 for each observation. All of the erythema and edema scores for each observation point were added together, and the sum was divided by the number of animals observed to determine an irritation score. The maximum irritation score was selected from the observation time yielding the highest irritation score.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: day 7
- Score:
- 6.8
- Max. score:
- 8
- Reversibility:
- not reversible
- Remarks on result:
- other: unspecified necrosis was observed in all animals at the end of the observation period. Only the time point with the highest mean score was reported.
Any other information on results incl. tables
Erythema and edema were present at each observation time through Day 21. The maximum irritation score of 6.8/8.0 was obtained at the Day 7 observation time. This score is consistent with a rating of "severe irritant". However, since necrosis was present on the test sites of all the animals, the test material was given a descriptive rating of "corrosive".
One male animal was found dead on Day 16 of the study. The cause of death was not mentioned.
Applicant's summary and conclusion
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