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EC number: 212-081-1 | CAS number: 760-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- publication
- Title:
- Five Toxicity Screening Studies with 2-Ethylhexanoyl chloride
- Author:
- PPG Ind. Inc., USA
- Year:
- 1 987
- Bibliographic source:
- TSCATS, OTS 0513463, Doc. I.D. 89-878000001
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for SIAM 27 - Acid Chlorides (AC) Category
- Author:
- OECD SIDS
- Year:
- 2 008
- Bibliographic source:
- OECD SIDS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-ethylhexanoyl chloride
- EC Number:
- 212-081-1
- EC Name:
- 2-ethylhexanoyl chloride
- Cas Number:
- 760-67-8
- Molecular formula:
- C8H15ClO
- IUPAC Name:
- 2-ethylhexanoyl chloride
- Details on test material:
- Purity of test material was not analytically confirmed. It was used as received from PPG Industries. Purity of that material is listed as > 98% on the MSDS
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated left eye served as a control.
- Amount / concentration applied:
- 100 µL
- Duration of treatment / exposure:
- In 3/9 animals the treated eyes were washed out after 30 sec; in all other animals, washing was not performed
- Observation period (in vivo):
- 21 d
- Number of animals or in vitro replicates:
- 9
- Details on study design:
- A test with fluorescein showed that the eyes were normal prior to testing. Test material (0.1 ml) was placed into the conjunctival sac of the right eye of each of 9 animals. The lids were held together for one second. Three of the nine treated eyes were each washed with room temperature deionized water for 1 minute, 30 seconds after treatment.
The treated eyes were examined for irritation 1, 24, 48 hours and 4, 7, 10, 14, 17 and 21 days after treatment. The corneas were re-examined after treatment with 0.2% fluorescein sodium ophthalmic solution after the 24 hour observation time. If staining was observed, staining was repeated after each subsequent evaluation time until staining no longer occurred.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Positive staining occurred in four nonwashed eyes, which resolved by 48 hours. Positive staining did not occur in any of the washed eyes.
Since corneal involvement and/or conjunctival irritation cleared in 7 days or less, the test material was categorized as Toxicity Category III.
Any other information on results incl. tables
Readings (nonwash) |
Animal (male) |
Cornea |
Iris |
Conjunctiva |
||
op |
ar |
red |
Sw |
|||
1 h |
1 |
0 |
0 |
0 |
3 |
2 |
2 |
+ |
3 |
0 |
2 |
3 |
|
3 |
1 |
2 |
0 |
3 |
3 |
|
24 h |
1 |
+ |
1 |
0 |
2 |
1 |
2 |
0 |
0 |
0 |
2 |
1 |
|
3 |
0 |
0 |
0 |
1 |
0 |
|
48 h |
1 |
0 |
0 |
0 |
1 |
0 |
2 |
0 |
0 |
0 |
1 |
1 |
|
3 |
0 |
0 |
0 |
0 |
0 |
|
72 h |
1 |
0 |
0 |
0 |
1 |
0 |
2 |
0 |
0 |
0 |
1x |
0 |
|
3 |
0 |
0 |
0 |
0 |
0 |
|
4 days |
1 |
0 |
0 |
0 |
1 |
0 |
2 |
0 |
0 |
0 |
1 |
0 |
|
3 |
0 |
0 |
0 |
0 |
0 |
|
7 days |
1 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
0y |
0 |
|
3 |
0 |
0 |
0 |
0x |
0 |
|
Mean (24-48-72 h) |
1 |
0 |
0.3 |
0 |
1.3 |
0.3 |
2 |
0 |
0 |
0 |
1.3 |
0.67 |
|
3 |
0 |
0 |
0 |
0.3 |
0 |
|
|
|
|
|
|
|
|
Readings (nonwash) |
Animal (male) |
Cornea |
Iris |
Conjunctiva |
||
op |
ar |
red |
sw |
|||
1 h |
4 |
+ |
1 |
0 |
2 |
3 |
5 |
2 |
2 |
1c |
2 |
2 |
|
6 |
+ |
2 |
0 |
2 |
3 |
|
24 h |
4 |
+ |
1 |
0 |
2 |
1 |
5 |
+ |
2 |
0 |
2 |
0 |
|
6 |
+ |
1 |
0 |
1 |
0 |
|
48 h |
4 |
0 |
0 |
0 |
1 |
0 |
5 |
0 |
0 |
0 |
1 |
0 |
|
6 |
0 |
0 |
0 |
1 |
0 |
|
72 h |
4 |
0 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
1 |
0 |
|
6 |
0 |
0 |
0 |
1x |
0 |
|
4 days |
4 |
0 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
0 |
0 |
0 |
|
6 |
0 |
0 |
0 |
0 |
0 |
|
7 days |
4 |
0 |
0 |
0 |
0x |
0 |
5 |
0 |
0 |
0 |
0x |
0 |
|
6 |
0 |
0 |
0 |
0 |
0 |
|
Mean (24-48-72 h) |
4 |
0 |
0.33 |
0 |
1 |
0.3 |
5 |
0 |
0.67 |
0 |
1.3 |
0 |
|
6 |
0 |
0.33 |
0 |
1 |
0 |
a - Animal exhibited apparent pain (squealing) at time of treatment.
+ slight dulling of normal luster
c - Constricted pupil.
x - Slight hair loss adjacent to eyelid.
y - Moderate hair loss adjacent to eyelid.
Readings (wash) |
Animal (female) |
Cornea |
Iris |
Conjunctiva |
||
op |
ar |
red |
Sw |
|||
1 h |
7 |
0 |
0 |
0 |
2 |
2 |
8 |
0 |
0 |
0 |
2 |
2 |
|
9 |
0 |
0 |
0 |
2 |
2 |
|
24 h |
7 |
0 |
0 |
0 |
1 |
0 |
8 |
0 |
0 |
0 |
1 |
1 |
|
9 |
0 |
0 |
0 |
1 |
0 |
|
48 h |
7 |
0 |
0 |
0 |
1 |
0 |
8 |
0 |
0 |
0 |
1 |
1 |
|
9 |
0 |
0 |
0 |
1 |
0 |
|
72 h |
7 |
0 |
0 |
0 |
1x |
1 |
8 |
0 |
0 |
0 |
0 |
0 |
|
9 |
0 |
0 |
0 |
1 |
0 |
|
4 days |
7 |
0 |
0 |
0 |
1 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
|
9 |
0 |
0 |
0 |
1 |
0 |
|
7 days |
7 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
|
9 |
0 |
0 |
0 |
0 |
0 |
|
Mean (24-48-72 h) |
7 |
0 |
0 |
0 |
1 |
0.3 |
8 |
0 |
0 |
0 |
0.67 |
0.67 |
|
9 |
0 |
0 |
0 |
1 |
0 |
|
|
|
|
|
|
|
|
x - Slight hair loss adjacent to eyelid.
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