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Diss Factsheets
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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable study report on the acute inhalative toxicity determined for male and female rats.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
- Principles of method if other than guideline:
- Inhalation studies were carried out according to methods from Farbenfabriken Bayer A.G., Werk Wuppertal-Elberfeld, Germany.
- GLP compliance:
- no
- Test type:
- other: acute toxicity inhalative
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
- Details on test material:
- - Name of test material (as cited in study report): "DIÄTHYLCARBONAT"
- Analytical purity:
German, original statement: "Für die Untersuchungen wurde eine chemisch reine Verbindung verwendet."
English, original statement translated: For the examinations a chemically pure compound was used.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Male and female Wistar-II-rats (weight 160-200 g), male and female Wistar-II-SPF-rats (weight 130-150 g) from the breeder Winkelmann, Kirchborchen, Germany;
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- other: probably whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gas chromatography; Details on methodology see under 8 Analytical methods in this IUCLID dossier
- Duration of exposure:
- 7 h
- Remarks on duration:
- on day 1
- Concentrations:
- 4h on day 1: 17.75 mg/L (males), 18.30 mg/L (females);
7 h on day 1: 19.50 mg/L (males, females); - No. of animals per sex per dose:
- 20
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: NOEC
- Effect level:
- 19.5 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: The endpoint NOEC was not mentioned in the study report and was assumed by the author of this IUCLID dossier as at this concentration no symptoms or deaths occurred.
- Mortality:
- 0
- Clinical signs:
- other: none
Any other information on results incl. tables
No signs of toxicity or irritation were observed in any animal, nor died any rats. No changes in the inner organs of the animals were seen. According to these results the author of this IUCLID dossier assumed that the NOEC for the test substance diethyl carbonate was 19.5 mg/L.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- According to the results of an acute toxicity inhalation study of the test substance diethyl carbonate in male and female rats, no signs of toxicity or irritation were observed at a concentration of 19.5 mg/L. At this concentration no deaths occurred. Regarding these results, the author of this IUCLID dossier assumed that the NOEC of diethyl carbonate (acute toxicity inhalation) is 19.5 mg/L. It can therefore be concluded that the substance should not be classified in any of the four categories. As the NOEC is assumed to be 19.5 mg/L it can be concluded that the corresponding LC50 should be much greater than 19.5 mg/L which represents the upper limit for classification in category 4 (10 < LC50 ≤ 20 mg/L, Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures (2009)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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