Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
other: presumably experimental
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Referenceopen allclose all

Reference Type:
other: data base data
Title:
No information
Author:
HSDB data base
Year:
2003
Bibliographic source:
HSDB database: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
Reference Type:
other: data base data
Title:
No information
Author:
SRC
Bibliographic source:
SRC
Reference Type:
publication
Title:
No information
Author:
Swann RL et al.
Year:
1983
Bibliographic source:
Res Rev 85: 17-28
Reference Type:
review article or handbook
Title:
No information
Author:
Hansch C et al
Year:
1995
Bibliographic source:
Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 76
Reference Type:
review article or handbook
Title:
No information
Author:
Lyman WJ et al.
Year:
1990
Bibliographic source:
Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9, 5-3, 7-5, 15-1 to 15-29
Reference Type:
review article or handbook
Title:
No information
Author:
Daubert TE, Danner RP
Year:
1996
Bibliographic source:
Physical and Thermodynamic Properties of Pure Chemicals Data Compilation Washington, DC: Taylor and Francis
Reference Type:
other: data base data
Title:
No information
Author:
Yalkowsky SH, Dannenfelser RM
Year:
1992
Bibliographic source:
Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ
Reference Type:
publication
Title:
No information
Author:
Osmon JL et al.
Year:
1972
Bibliographic source:
pp. 66-75 in Proc Int Biodeterior Symp. 2nd
Reference Type:
publication
Title:
No information
Author:
Franke C et al.
Year:
1994
Bibliographic source:
; Chemosphere 29: 1501-14
Reference Type:
publication
Title:
No information
Author:
Meylan WM et al.
Year:
1999
Bibliographic source:
Environ Toxicol Chem 18: 664-72

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
name of substance as cited on HSDB data base:
diethyl carbonate

Results and discussion

Transformation products:
yes

Any other information on results incl. tables

Additional published results, info from HSDB database (http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB):

AQUATIC FATE: Based on a classification scheme (1), an estimated Koc value of 100 (SRC), determined from a log Kow of 1.21 (2) and a regression-derived equation (3), indicates that diethyl carbonate is not expected to adsorb to suspended solids and sediment in water (SRC). Volatilization from water surfaces is expected to be an important fate process (3) based upon an estimated Henry's Law constant of 8.9X10-5 atm-cu m/mole (SRC), calculated from a vapor pressure of 10.8 mm Hg (4) and water solubility of 18,800 mg/l (5). Using this Henry's Law constant and an estimation method (3), volatilization half-lives for a model river and model lake are 8 hours and 8 days, respectively (SRC). Diethyl carbonate may undergo hydrolysis in water since esters are susceptible to hydrolysis (3). Although no biodegradation data for diethyl carbonate was located, chemically similar short alkyl chain esters have been shown to biodegrade (6). According to a classification scheme (7), an estimated BCF of 2 (SRC), from its log Kow (2) and a regression-derived equation (8), suggests the potential for bioconcentration in aquatic organisms is low (SRC).

References:

(1) Swann RL et al; Res Rev 85: 17-28 (1983)

(2) Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 76 (1995)

(3) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9, 5-3, 7-5, 15-1 to 15-29 (1990)

(4) Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals Data Compilation Washington, DC: Taylor and Francis (1996)

(5) Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ (1992)

(6) Osmon JL et al; pp. 66-75 in Proc Int Biodeterior Symp. 2nd (1972)

(7) Franke C et al; Chemosphere 29: 1501-14 (1994)

(8) Meylan WM et al; Environ Toxicol Chem 18: 664-72 (1999)

Further remarks from the author of this substance-specific data set:

The substance is readily biodegradable according to a study of good quality generated by Bayer. Furthermore, unproblematic substances are generated when diethyl carbonate hydrolyses: carbon dioxide and ethanol.

Applicant's summary and conclusion