Registration Dossier

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: HSDB data (peer reviewed as stated there); original data source from Lewis (1996) could not be reviewed. No details on background data of LDLo value delivered (materials, methods, results).

Data source

Referenceopen allclose all

Reference Type:
other: data base data
Title:
No information
Author:
HSDB
Year:
2003
Bibliographic source:
HSDB database: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB
Reference Type:
review article or handbook
Title:
Sax's Dangerous Properties of Industrial Materials
Author:
Lewis, R.J. (ed.)
Year:
1996
Bibliographic source:
9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, p. 1171

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
subcutaneous

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
8 500 mg/kg bw
Remarks on result:
other: original as in data source (exposure via subcutaneous route): LD50 Rat scu 8500 mg/kg

Applicant's summary and conclusion

Conclusions:
The high LD50 Rat scu 8500 mg/kg suggests a low acute toxicity of diethyl carbonate via the subcutaneous exposure route.