Registration Dossier

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Reliable review from BG Chemie Germany (Professional Association Chemistry in Germany) about the toxicology of diethyl carbonate. The BG Chemie is the central institution to facilitate workplace safety in the chemical industry in Germany. It is referred to the original data source which is a publication.
Principles of method if other than guideline:
No information if data generation was in accordance with an official guideline.
GLP compliance:
no

As stated in the review of BG Chemie (1994):

7. Experimental results

7.1 Toxicokinetics and metabolism

Enzymatic cleavage of carbonic acid diethyl ester occurred on incubation with homogenates of bovine kidney or mucous membrane from the small intestine. The increase in pressure caused by liberated CO2 was measured manometrically in a Warburg apparatus (Lang et al., 1966).

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
As an ester diethyl carbonate may be metabolised to ethanol and CO2 in the body, in particular in the intestine or in the kidneys. This assumption may be supported by the results of Lang et al. who found the generation of CO2 when the substance was in contact with homogenates (and therefore enzymes) of bovine kidney and intestinal membrane. Carbon dioxide is a natural metabolite in the human body. Ethanol has a known toxicity profile and is also metabolised without accumulation in the body. If this metabolism takes place the risks associated with it would be limited.

Description of key information

Lang et al. (1966) found the generation of CO2 when diethyl carbonate was in contact with intestinal enzymes. 

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

As an ester diethyl carbonate may be metabolised to ethanol and CO2 in the body, in particular in the intestine or in the kidneys. This assumption may be supported by the results of Lang et al. who found the generation of CO2 when the substance was in contact with homogenates (and therefore enzymes) of bovine kidney and intestinal membrane. Carbon dioxide is a natural metabolite in the human body. Ethanol has a known toxicity profile and is also metabolised without accumulation in the body. If this metabolism takes place the risks associated with it would be limited.