Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Lang et al. (1966) found the generation of CO2 when diethyl carbonate was in contact with intestinal enzymes. 

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

As an ester diethyl carbonate may be metabolised to ethanol and CO2 in the body, in particular in the intestine or in the kidneys. This assumption may be supported by the results of Lang et al. who found the generation of CO2 when the substance was in contact with homogenates (and therefore enzymes) of bovine kidney and intestinal membrane. Carbon dioxide is a natural metabolite in the human body. Ethanol has a known toxicity profile and is also metabolised without accumulation in the body. If this metabolism takes place the risks associated with it would be limited.