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Diss Factsheets
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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Details about origin of study report/performing laboratory. No info about origin of method, the analyses of symptoms, the batch and purity of "Diätyhlcarbonat". However, details about test animals and test conditions were stated and as no symptoms and stable body weights were found for a relatively high number of animals (10) the report is regarded as reliable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
- Principles of method if other than guideline:
- single dose of 5 ml/kg bw administered by a stomach probe to 10 male rats; observation of clinicals symptoms over a period of 14 days
- GLP compliance:
- no
- Test type:
- other: single dose limit test
- Limit test:
- yes
Test material
- Reference substance name:
- Diäthylcarbonat
- IUPAC Name:
- Diäthylcarbonat
- Details on test material:
- - Name of test material (as cited in study report): Diäthylcarbonat
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Lot/batch No.: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: SPF rats, breeding strain Wistar TNO W 74
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen
- Age at study initiation: ca. 9 - 14 weeks
- Weight at study initiation: 169 g
- Fasting period before study: no data
- Housing: kept in conventional Makrolon cages type III and on dust-free wood granulate
- Grouping: animals kept in groups of 5
- Diet ad libitum: Altromin R 1324 (manufacturer: Altromin GmbH, Lage)
- Water ad libitum: tap drinking water
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature, 22 +/- 1.5
- Humidity (%): 60 +/- 5
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 / 12 (artificial lighting from 7 am to 7 pm)
IN-LIFE DATES: From: To: no data
Identification of animals: with picric acid marking on fur and codes on cages
Administration / exposure
- Route of administration:
- other: oral, with a rigid metal stomach probe
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5 ml/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing at the time of administration and at the end of the 14-day observation period (alive animals);
examinations several times/d on 1st day (day of administration), normally 2 times/d and on weekends and holidays 1 time/d.
- Necropsy of survivors performed: yes/no: no data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
weighing of body weights performed, limited data about other performed examinations:
"recording type, beginning, duration and intensity of clinical symptoms"
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: valid for all test animals (10)
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 4 876 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: This value was calculated by the author of this IUCLID dossier by multiplying the density of the test substance (0.9752 g/mL) with the measured LD50 volume (5 mL).
- Mortality:
- no mortality
- Clinical signs:
- other: none
Any other information on results incl. tables
Information extracted from the study report:
Based on the test results the LD50 is > 5 ml/kg bw for male rats. No symptoms developed and the body weights were stable. Therefore, Diäthylcarbonat (engl.: diethyl carbonate) has proven to be relatively non-toxic in this acute toxicity test.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: as concluded in study report
- Conclusions:
- According to the determined LD50 of > 5.0 mL/kg (4876 mg/kg) of the test substance diethyl carbonate by oral administration to male Wistar rats, the test substance is practically nontoxic.
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