Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- other: Secondary reference IUCLID4
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Title:
- No information
- Author:
- Minden H et al.
- Year:
- 1 969
- Bibliographic source:
- Dtsch. Gesundheitsw. 24 (40), 1894-1897
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Duration of treatment / exposure:
- 9 Tage
- Frequency of treatment:
- 5 Applikationen im Abstand von je 2 Tagen
Doses / concentrations
- Remarks:
- Doses / Concentrations:
30 mg/kg
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: bis 28 Tage nach Versuchsbeginn
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Bei biochemischen Untersuchungen nach 2 bzw. 4 Wochen
wurde eine signifikante Erhoehung der
Glucose-6-Phosphat-Dehydrogenase, der
Isocitronensaeuredehydrogenase, der Sorbit-Dehydrogenase,
der GOT und des Gesamtcholesterols in der Leber
festgestellt. Die Aktivitaet der alkal. Phosphatase war
reduziert. Die Aktivitaet der Glutaminsaeure-Dehydrogenase
war nur nach 2 Wochen erhoeht, auch das Lebergewicht war
nur nach 2 Wochen erhoeht, nach 4 Wochen wurden wieder
normale Werte bestimmt. Dies deutet nach Angaben der
Autoren darauf hin, dass die beobachteten Veraenderungen
reversibel waren.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
