Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- other: Secondary reference IUCLID4
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Title:
- No information
- Author:
- Courtney K.D. et al.
- Year:
- 1 981
- Bibliographic source:
- J. Environ. Sci. Health, B17(4), 381-391
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 6.-16. Tag der Traechtigkeit
- Frequency of treatment:
- taeglich
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50; 100; 150 mg/kg
Basis:
- Control animals:
- yes
- Details on study design:
- Sex: female
Duration of test: bis zum 17. Tag der Traechtigkeit
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Die Versuchs- und Kontrollgruppen bestanden aus je 10 - 12
Tieren.
In der hoechsten Dosierung starben 75 % der Muttertiere,
bei den restlichen 25 % konnte keine Traechtigkeit mehr
festgestellt werden. In der 100 mg/kg Dosisgruppe war die
maternale Koerpergewichtsentwicklung signifikant
reduziert. Der Prozentsatz lebender Foeten und der der
Foetenmortalitaet entsprachen der Kontrolle. Das
Foetengewicht in der 100 mg/kg Dosisgruppe war signifikant
reduziert. Die Zahl der Foeten mit Missbildungen war
gegenueber der Kontrolle nicht erhoeht, jedoch wurde bei
den Foeten eine allgemeine Retardierung in der Entwicklung
festgestellt. In der 50 mg/kg Dosisgruppe wurde weder
maternale Toxizitaet noch eine embryo-/foetotoxische oder
teratogene Wirkung festgestellt.
Applicant's summary and conclusion
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