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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Additional information
Short description of key information:
No valid data available.

Effects on developmental toxicity

Description of key information
See discussion section.
Additional information

In NTP TR 275 a summary is given of reproductive toxicity studies (page 18):

Malformations and high rates of embryo mortality occurred when chick embryos were administered 2-chloroethanol at doses of 50 or 100 mg/kg (egg weight) at 0 or 96 hours of incubation (Verrett, 1974).

Fetotoxicity and maternal toxicity were produced when the compound was administered by gavage to pregnant Swiss CD-1 mice on days 4-12 of gestation (RTI, 1983a).

No effect on the mother or offspring occurred when 2-chloroethanol was administered in drinking water to Swiss CD-1 mice on days 6-16 of gestation. No teratogenic effects were noted in New Zealand white rabbits administered 2-chloroethanol intravenously at doses (36 mg/kg per day) that produced significant levels of fetotoxicity or maternal toxicity (RTI, 1983b).

Justification for classification or non-classification

Not classified. No valid data on fertility available. In developmental studies effects were only observed at maternal toxic levels.

Additional information